Dilated cardiomyopathy and cocaine abuse. Report of two cases
The American Journal of MedicinePublished 1 October 1986
Roy S. Wiener, Jeffrey T. Lockhart, Ronald G. Schwartz
Citations152
SJR quartileQ1
SJR score1.00
SNIP1.04
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TL;DR
Long-term cocaine use may cause dilated cardiomyopathy and recurrent myocardial infarction, even in the absence of atherosclerotic epicardial coronary artery disease.
Abstract
Two young patients with dilated cardiomyopathies associated with long-term use of cocaine are described. A 42-year-old male cocaine abuser with normal coronary arteries experienced recurrent myocardial infarction, with development of a dilated, globally hypocontractile left ventricle. The second patient, a 28-year-old woman with a prominent history of inhaling vaporized cocaine ("free-basing"), presented with symptoms and signs of biventricular heart failure and was found to have a dilated cardiomyopathy. The clinical spectrum of cocaine cardiotoxicity is reviewed, and pathophysiologic mechanisms of cocaine-induced cardiomyopathy are discussed. Long-term cocaine use may cause dilated cardiomyopathy and recurrent myocardial infarction, even in the absence of atherosclerotic epicardial coronary artery disease.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
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