Isradipine in Patients with Acute Ischaemic Cerebral Infarction
DrugsPublished 1 January 1990
Alberto Azcona, X. Lataste
Citations30
SJR quartileQ1
SJR score3.36
SNIP3.43
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A randomised, double-blind, placebo-controlled multicentre study was started in up to 600 patients with acute ischaemic brain infarction to improve the neurological and functional outcome of human stroke patients.
Abstract
Calcium-related mechanisms are an integral part of metabolic reactions during acute cerebral infarction. In an animal model of stroke, the calcium antagonist isradipine was shown to protect neurons against ischaemia. In order to improve the neurological and functional outcome of human stroke patients, a randomised, double-blind, placebo-controlled multicentre study was started in up to 600 patients with acute ischaemic brain infarction. Since early treatment is considered to be of great importance, patients must be recruited no more than 12 hours after stroke onset. Medical, ECG, laboratory, neurological and functional evaluations are conducted for up to 90 days after stroke.
Keywords
MedicineNeuroscience
ScienceCalcium Dependence of Toxic Cell Death: A Final Common Pathway
1,486 Citations1979Francis A.X. Schanne, Agnes B. Kane +2 more
Viability, as determined by trypan blue exclusion correlated well with other indices of viability such as plating efficiency and the hydrolysis of fluorescein diacetate, and it is concluded that the cells are killed by processes that involve at least two steps.
New England Journal of MedicineA Randomized Trial Comparing Ticlopidine Hydrochloride with Aspirin for the Prevention of Stroke in High-Risk Patients
1,196 Citations1989William K. Hass, J. Donald Easton +6 more
It is concluded that ticlopidine was somewhat more effective than aspirin in preventing strokes in this population, although the risks of side effects were greater.
Journal of the American Statistical AssociationThe Design and Analysis of Sequential Clinical Trials.
638 Citations1985David Harrington, John Whitehead
New England Journal of MedicineA Controlled Trial of Nimodipine in Acute Ischemic Stroke
425 Citations1988H. J. Gelmers, K. J. Gorter +2 more
The data suggest that patients with acute ischemic stroke may benefit from early treatment with nimodipine, but this therapeutic effect appears to be limited to men.
Journal of Cerebral Blood Flow & MetabolismCalcium Overload in Selectively Vulnerable Neurons of the Hippocampus during and after Ischemia: An Electron Microscopy Study in the Rat
363 Citations1984R. P. Simon, T. Griffiths +3 more
The role of excessive calcium entry and mitochondrial calcium overload during the reperfusion period in determining the death of selectively vulnerable neurons is discussed.
Epidemiology of Cerebrovascular Disease
301 Citations1969John F. Kurtzke
StrokeEpidemiology of stroke in Tilburg, the Netherlands. The population-based stroke incidence register: 2. Incidence, initial clinical picture and medical care, and three-week case fatality.
182 Citations1982B. Herman, A. C. M. Leyten +4 more
The results of a prospective population study of stroke in Tilburg are reported, and patients with speech problems, as opposed to those without, demonstrated more extreme motor deficit when such occurred.
StrokeXIV. Cerebral ischemia: the role of thrombosis and of antithrombotic therapy. Study group on antithrombotic therapy.
140 Citations1977Edward Genton, Henry J.M. Barnett +3 more
In delineating the several clinical types of focal ischemic disease and outlining the causes of cerebral ischemia and infarction, the study group considers the problems of data interpretation in the face of inconsistent terminology and critically reviews earlier reports of clinical trials of anticoagulants, platelet function suppressants, and thrombolytic agents.
StrokeCalcium antagonists reduce the extent of infarction in rat middle cerebral artery occlusion model as determined by quantitative magnetic resonance imaging.
138 Citations1986A. Sauter, Markus Rudin
StrokeIntravenous prostacyclin in acute nonhemorrhagic stroke: a placebo-controlled double-blind trial.
79 Citations1987Chung Y. Hsu, Edward Faught +6 more
A lack of therapeutic efficacy of prostacyclin in a defined population of patients with nonhemorrhagic cerebral infarction is suggested.
Acta Neurologica ScandinavicaPrevalence of stroke in a district of Copenhagen
70 Citations2009Per Soelberg Sørensen, Gudrun Boysen +2 more
From the city center of Copenhagen, almost 20,000 people, 20 years of age and older, were randomly selected for examination after age and sex stratification, and the participation rate was 72%.
Acta NeurochirurgicaEffect of nimodipine (Bay e 9736) on postischaemic cerebrovascular reactivity, as revealed by measuring regional cerebral blood flow (rCBF)
68 Citations1982H. J. Gelmers
Regional cerebral blood flow was measured in 10 patients with an acute ischaemic stroke, involving the cerebral cortex, before and after intravenous injection of a single dose of nimodipine (Bay e 9736), and the presence was concluded of an inverse steal phenomenon.
StrokeDouble-blind controlled trial of prostacyclin in cerebral infarction.
54 Citations1985J F Martin, Neveen A. T. Hamdy +6 more
This study has not been able to demonstrate that prostacyclin is effective in the treatment of ischaemic stroke, but due to the sample size the chance of proving this statistically (the power) was small.
PubMedThe National Survey of Stroke. Economic impact.
51 Citations1981Adelman Sm
The estimated economic costs of stroke in 1976 amounted to $7,363,784,000 (based on a 6 percent gross, or 4 percent net, discount rate); almost half were direct costs, and the majority of these were related to inpatient hospital and nursing facility care.
Progress in brain researchMolecular Mechanisms of Ischemic Brain Damage
48 Citations1985
Saccadic Eye Movements Change Blindness and Transsaccadic Integration Smooth Pursuit Eye Movement Eye-Hand Coordination Clinical Aspects of Eye Movement Research.
PubMed[Development of a neurological score for the clinical evaluation of sylvian infarctions].
44 Citations1983J.M. Orgogozo, Rudy Capildeo +7 more
The good agreement observed between inter-rater variations suggests that the neurological score is reliable but does not inform on its sensitivity, and the neurological and the functional score should be regarded as complementary and used together as criteria of clinical assessment.
Neurochemical PathologyReduction of neural damage in irreversible cerebral ischemia by calcium antagonists
36 Citations1988A. Sauter, Markus Rudin +1 more
The appearance and evolution of brain infarcts in spontaneously hypertensive rats (SHR), after occlusion of the middle cerebral artery (MCA), were detected with MRI and histology and the functional consequences of these morphological effects of isradipine were reflected by the parallel improvement of a neurological score.