Zidovudine Use to Reduce Perinatal HIV Type 1 Transmission in an Urban Medical Center

JAMAPublished 15 May 1996

Andrew Wiznia

DOI10.1001/jama.1996.03530430048038

Source URL

Citations56

SJR quartileQ1

SJR score5.35

SNIP10.71

TL;DR

Zidovudine therapy to interrupt vertical transmission of HIV was not widely used by these HIV-infected pregnant women and further studies evaluating factors affecting the acceptance and use of recently published public health recommendations are needed.

Abstract

Zidovudine therapy to interrupt vertical transmission of HIV was not widely used by these HIV-infected pregnant women. Further studies evaluating factors affecting the acceptance and use of recently published public health recommendations are needed.

Keywords

Medicine

New England Journal of MedicineReduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment

3,741 Citations1994Edward M. Connor, Rhoda Sperling +18 more

In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds.

View PDF

Obstetrical & Gynecological SurveyReduction of Maternal-Infant Transmission of Human Immunodeficiency Virus 1 with Zidovudine Treatment

1,825 Citations1995Edward M. Connor, Rhoda Sperling +18 more

It was shown that AZT decreased the maternal-infant transmission of HIV and helped decrease infant mortality due to the viral infection.

PubMedSurveillance for smoking-attributable mortality and years of potential life lost, by state--United States, 1990.

799 Citations1994Nelson De, Kirkendall Rs +5 more

The number of deaths attributable to cigarette smoking in 1990 remained high and efforts are needed to control tobacco use in all states.

Epidemiologic ReviewsEpidemiology of Tobacco Use and Dependence

286 Citations1995Gary A. Giovino, Jack E. Henningfield +3 more

Public health action continues to be warranted to reduce the substantial morbidity and mortality caused by tobacco use and involves preventing the onset of use, treating tobacco dependence, protecting non-smokers from exposure to secondhand smoke, promoting nonsmoking messages while limiting the effect of tobacco advertising and promotion on young people, increasing the real (inflation-adjusted) price of tobacco products, and regulating tobacco products.

AIDSAssociation of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission

181 Citations1996Evelyn M. Rodriguez, Lynne Mofenson +9 more

Overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternalhard drug use was associated with perinatal transmission.

JAMAPrevalence and Incidence of Vertically Acquired HIV Infection in the United States

129 Citations1995Susan F. Davis

These results provide a basis for estimating medical and other resource needs for HIV-infected women and their children and for measuring the impact of interventions to reduce vertical transmission of HIV.

Journal of Acquired Immune Deficiency Syndromes & Human RetrovirologyThe Consequences of a Positive Prenatal HIV Antibody Test for Women

73 Citations1995Patricia Lester, J. Colin Partridge +2 more

Despite added social support and medical treatments, HIV-positive women showed higher levels of health care discrimination, personal isolation, and psychological sequelae than their seronegative counterparts.

Clinical Obstetrics & GynecologyMaternal, Placental, and Fetal Pathophysiology of Cocaine Exposure During Pregnancy

67 Citations1993Mark A. Plessinger, James R. Woods

Attempts to characterize the fetal effects of cocaine exposure during pregnancy in order to formulate a "fetal cocaine syndrome" have revealed a wide spectrum of fetal effects, and it appears that even a single exposure may produce infarction, edema, and tissue necrosis.

New England Journal of MedicineEthical Challenges Posed by Zidovudine Treatment to Reduce Vertical Transmission of HIV

65 Citations1994Ronald Bayer

In February 1994 the Data and Safety Monitoring Board of the National Institute of Allergy and Infectious Diseases recommended the interruption of a clinical trial designed to determine whether the use of nanoparticles in the treatment of influenza is safe and effective.

New England Journal of MedicineReducing the Risk of Maternal-Infant Transmission of HIV: A Door Is Opened

35 Citations1994Martha F. Rogers, Harold W. Jaffe

A large number of HIV-infected women in sub-Saharan Africa give birth to babies infected with the virus through Caesarean sections, which can be fatal for both the mother and the baby.