Three-Dimensional Analysis With MRI and PET of the Size, Shape, and Function of the Thalamus in the Schizophrenia Spectrum
American Journal of PsychiatryPublished 1 August 1999
Erin A. Hazlett, Monte S. Buchsbaum, William Byne, Tse-Chung Wei, Jacqueline Spiegel-Cohen, Craig Geneve
Citations203
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
Compared thalamic size, shape, and metabolic activity in unmedicated patients with schizophrenia and schizotypal personality disorder to findings in age- and sex-matched healthy control subjects, schizophrenic patients showed significant metabolism and shape differences from control subjects in selective subregions of the thalamus.
Abstract
Schizophrenic patients showed significant metabolism and shape differences from control subjects in selective subregions of the thalamus, whereas patients with schizotypal personality disorder showed only a difference in shape. Because the mediodorsal and anterior nuclei have different connections with limbic and prefrontal structures, the anterior thalamic shrinkage and mediodorsal metabolic and shape changes might relate to the different clinical pictures in schizotypal personality disorder and schizophrenia.
Keywords
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