Lifetime of plasma cells in the bone marrow
NaturePublished 10 July 1997Open access
Rudolf A. Manz, Andreas Thiel, Andreas Radbruch
Citations851
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
It is shown that antibody-secreting plasma cells from bone marrow are as long-lived as memory B cells.
Abstract
Immune protection is based on long-lived memory cells and effector cells, which are either cytotoxic or secrete antibodies. The lifespan of these effector cells has not so far been determined. Here we show that antibody-secreting plasma cells from bone marrow are as long-lived as memory B cells.
Keywords
Immunology and MicrobiologyMedicine
NatureMaintenance of B-cell memory by long-lived cells generated from proliferating precursors
318 Citations1990Birgit Schittek, Klaus Rajewsky
It is shown that after an initial phase of extensive proliferation after primary immunization, memory cells can persist in the organism for extended periods of time in the absence of cell division.