Impaired Learning and Decreased Cortical Norepinephrine after Bilateral Locus Coeruleus Lesions
SciencePublished 17 August 1973
Gill Anlezark, Timothy J. Crow, A. P. Greenway
Citations264
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
As assessed in this situation, learning was absent in those rats with the most complete ablations of the locus coeruleus, although these rats showed normal weight gain and normal motor and exploratory activity.
Abstract
Bilateral lesions of the nucleus locus coeruleus in rats deplete the cerebral cortex of norepinephrine and significantly diminish the rate of increase of running for food reward in a simple L-shaped runway. As assessed in this situation, learning was absent in those rats with the most complete ablations of the locus coeruleus, although these rats showed normal weight gain and normal motor and exploratory activity.
Keywords
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