Implications for the Neural Basis of Social Cognition for the Study of Schizophrenia
American Journal of PsychiatryPublished 1 May 2003
Amy E. Pinkham, David L. Penn, Diana O. Perkins, Jeffrey A. Lieberman
Citations454
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TL;DR
How the neural basis of social cognition may inform future clinical research in schizophrenia is discussed, to better elucidate the underlying mechanisms for social cognitive and social behavioral impairments in schizophrenia as well as provide potential targets for treatment and drug development.
Abstract
These parallels might help to better elucidate the underlying mechanisms for social cognitive and social behavioral impairments in schizophrenia as well as provide potential targets for treatment and drug development.
Keywords
PsychologyNeuroscience
Trends in Cognitive SciencesThe distributed human neural system for face perception
4,950 Citations2000J.V. Haxby, James V. Haxby +2 more
A model for the organization of this system that emphasizes a distinction between the representation of invariant and changeable aspects of faces is proposed and is hierarchical insofar as it is divided into a core system and an extended system.
American Journal of PsychiatryWhat are the functional consequences of neurocognitive deficits in schizophrenia?
3,492 Citations1996M F Green
Verbal memory and vigilance appear to be necessary for adequate functional outcome in schizophrenic patients and may prevent patients from attaining optimal adaptation and hence act as "neurocognitive rate-limiting factors."
Schizophrenia BulletinNeurocognitive Deficits and Functional Outcome in Schizophrenia: Are We Measuring the "Right Stuff"?
2,965 Citations2000M. F. Green, Robert S. Kern +2 more
This paper will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome.
Trends in Cognitive SciencesSocial perception from visual cues: role of the STS region
2,478 Citations2000Truett Allison, Truett Allison +4 more
Single-cell recordings in monkeys, and neurophysiological and neuroimaging studies in humans, reveal that cerebral cortex in and near the superior temporal sulcus (STS) region is an important component of this perceptual system.
Journal of NeuroscienceMasked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
2,219 Citations1998Paul J. Whalen, Scott L. Rauch +4 more
This study, using fMRI in conjunction with masked stimulus presentations, represents an initial step toward determining the role of the amygdala in nonconscious processing.
NatureA differential neural response in the human amygdala to fearful and happy facial expressions
2,022 Citations1996J. S. Morris, Chris Frith +5 more
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.
Journal of NeuroscienceDifferent Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making
2,004 Citations1999Antoine Bechara, Hanna Damásio +2 more
The results suggest that amygdala damage is associated with impairment in decision-making and that the roles played by the amygdala and VMF in decision -making are different.
ScienceInteracting Minds--A Biological Basis
1,719 Citations1999Chris Frith, Uta Frith
Observations suggest that the ability to mentalize has evolved from a system for representing actions, and medial prefrontal regions are concerned with explicit representation of states of the self.
American Journal of PsychiatryMeta-Analysis of Regional Brain Volumes in Schizophrenia
1,647 Citations2000Ian C. Wright, Sophia Rabe‐Hesketh +4 more
NatureA specific neural substrate for perceiving facial expressions of disgust
1,614 Citations1997Mary L. Phillips, Andrew W. Young +10 more
Functional magnetic resonance imaging was used to examine the neural substrate for perceiving disgust expressions and found the neural response to facial expressions of disgust in others is thus closely related to appraisal of distasteful stimuli.
Nature NeuroscienceImpairment of social and moral behavior related to early damage in human prefrontal cortex
1,548 Citations1999Steven W. Anderson, Antoine Bechara +3 more
Early-onset prefrontal damage resulted in a syndrome resembling psychopathy, suggesting that the acquisition of complex social conventions and moral rules had been impaired.
CognitionOther minds in the brain: a functional imaging study of “theory of mind” in story comprehension
1,520 Citations1995Paul C. Fletcher
The localisation of brain regions involved in normal attribution of mental states and contextual problem solving is feasible and may have implication for the neural basis of autism.
Journal of Cognitive NeuroscienceFrontal Lobe Contributions to Theory of Mind
1,495 Citations1998Valerie E. Stone, Simon Baron‐Cohen +1 more
Patients with bilateral damage to orbito-frontal cortex and unilateral damage in left dorsolateral prefrontal cortex performed similarly to individuals with Asperger's syndrome, performing well on simpler tests and showing deficits on tasks requiring more subtle social reasoning, such as the ability to recognize a faux pas.
Behavioral and Cognitive Neuroscience ReviewsRecognizing Emotion from Facial Expressions: Psychological and Neurological Mechanisms
1,413 Citations2002Ralph Adolphs
Investigations are being extended to nonhuman primates, to infants, and to patients with psychiatric disorders, to elucidate some of the mechanisms behind recognition of emotion from facial expressions.
NeuropsychologiaReading the mind in cartoons and stories: an fMRI study of ‘theory of mind’ in verbal and nonverbal tasks
1,409 Citations2000Helen L. Gallagher, Francesca Happé +4 more
Brain activation during the theory of mind condition of a story task and a cartoon task showed considerable overlap in the medial prefrontal cortex (paracingulate cortex), which is discussed in relation to the cognitive mechanisms underpinning the authors' everyday ability to 'mind-read'.
Current Opinion in NeurobiologyThe neurobiology of social cognition
1,396 Citations2001Ralph Adolphs
Open questions remain about the domain-specificity of social cognition, about its overlap with emotion and with communication, and about the methods best suited for its investigation.
Schizophrenia ResearchSchizophrenia, symptomatology and social inference: Investigating “theory of mind” in people with schizophrenia
1,335 Citations1995Rhiannon Corcoran, Gavin Mercer +1 more
The notion that some patients with schizophrenia have difficulties with tasks requiring 'theory of mind' skills and that this deficiency is symptom specific is supported.
NeuroImageMovement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional Movement Patterns
1,315 Citations2000Fulvia Castelli, Francesca Happé +2 more
A functional neuroimaging study with positron emission tomography in which six healthy adult volunteers were scanned while watching silent computer-presented animations showed increased activation in association with mental state attribution in four main regions: medial prefrontal cortex, temporoparietal junction, basal temporal regions, and extrastriate cortex.
NeuropsychologiaDecision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers
1,176 Citations2001Antoine Bechara, Sara L. Dolan +4 more
The hypothesis that impairment in decision-making linked to a dysfunctional VM cortex is associated with at least a sub-group of substance dependent individuals (SD) is supported.
NatureThe human amygdala in social judgment
1,041 Citations1998Ralph Adolphs, Daniel Tranel +1 more
This investigation into the hypothesis that the human amygdala is required for accurate social judgments of other individuals on the basis of their facial appearance finds three subjects with complete bilateral amygdala damage to judge faces of unfamiliar people with respect to two attributes important in real-life social encounters: approachability and trustworthiness.
NeuroImageMind Reading: Neural Mechanisms of Theory of Mind and Self-Perspective
1,010 Citations2001Kai Vogeley, P. Bussfeld +8 more
Divergent neural activations in response to TOM and SELF suggest that these important differential mental capacities of human self-consciousness are implemented at least in part in distinct brain regions.
Journal of NeuroscienceDifferential Sensitivity of Human Visual Cortex to Faces, Letterstrings, and Textures: A Functional Magnetic Resonance Imaging Study
1,002 Citations1996Aina Puce, Truett Allison +3 more
Different regions of ventral extrastriate cortex are specialized for processing the perceptual features of faces and letterstrings, and that these regions are intermediate between earlier processing in striate and peristriates cortex, and later lexical, semantic, and associative processing in downstream cortical regions.
Nature NeuroscienceAutomatic and intentional brain responses during evaluation of trustworthiness of faces
996 Citations2002Joel S. Winston, Bryan A. Strange +2 more
The findings extend a proposed model of social cognition by highlighting a functional dissociation between automatic engagement of amygdala versus intentional engagement of STS in social judgment.
Proceedings of the National Academy of SciencesA functional imaging study of cooperation in two-person reciprocal exchange
992 Citations2001Kevin McCabe, Daniel Houser +3 more
It is hypothesized that this area is involved in integrating theory-of-mind processing with cooperative actions in prefrontal cortex, and data is reported from a functional MRI experiment designed to test this hypothesis.
BrainImpaired social response reversal: A case of `acquired sociopathy'
875 Citations2000James Blair
A patient who, following trauma to the right frontal region, including the orbitofrontal cortex, presented with 'acquired sociopathy' is reported, suggesting that J.S.'s impairment is due to a reduced ability to generate expectations of others' negative emotional reactions, in particular anger.
Clinical Psychology ReviewPERSECUTORY DELUSIONS: A REVIEW AND THEORETICAL INTEGRATION
872 Citations2001Richard P. Bentall, Rhiannon Corcoran +3 more
It is argued that biases in this cycle cause negative events to be attributed to external agents and hence contribute to the building of a paranoid world view, and a new integrative model is proposed that builds on this work.
Trends in Cognitive SciencesSocial cognition and the human brain
869 Citations1999Ralph Adolphs, Ralph Adolphs
This work focuses on the amygdala, ventromedial frontal cortices, and right somatosensory-related cortex, which appear to mediate between perceptual representations of socially relevant stimuli and retrieval of knowledge.
Psychological MedicineExploring ‘theory of mind’ in people with schizophrenia
803 Citations1996Chris Frith, Rhiannon Corcoran
Mentalizing ability was studied in symptomatic schizophrenic patients and non-symptomatic controls, consistent with the hypothesis that certain of the positive symptoms of schizophrenia reflect an impairment in the ability to infer the mental states of others.
British Journal of Clinical PsychologyCognitive approaches to delusions: A critical review of theories and evidence
801 Citations1999Philippa Garety, Daniel Freeman
A multi-factorial model of delusion formation and maintenance incorporating a data-gathering bias and attributional style, together with other factors (e.g. perceptual processing, meta-representation) is consistent with the current evidence.
Archives of General PsychiatryHippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging
756 Citations1998Michael D. Nelson, Andrew J. Saykin +2 more
Schizophrenia is associated with a bilateral volumetric reduction of the hippocampus and probably of the amygdala as well, which reinforces the importance of the medial temporal region in schizophrenia and is consistent with frequently reported memory deficits in these patients.
Clinical Psychology ReviewEmotion recognition via facial expression and affective prosody in schizophrenia
718 Citations2002Jane Edwards, Henry J. Jackson +1 more
This paper includes a comprehensive analysis of the schizophrenia facial affect recognition research over the past decade and the schizophrenia literature on affective prosody, and provides the first review of the schizophrenic literature on multichannel emotion recognition research.
Journal of Cognitive NeuroscienceI. The Neurocognitive Profile of Williams Syndrome: A Complex Pattern of Strengths and Weaknesses
711 Citations2000Ursula Bellugi, Liz Lichtenberger +3 more
The rare, genetically based disorder, Williams syndrome, produces a constellation of distinctive cognitive, neuroanatomical, and electrophysiological features which are explored through the series of studies reported here.
Cognitive NeuropsychologyFacial Emotion Recognition after Bilateral Amygdala Damage: Differentially Severe Impairment of Fear
685 Citations1996Andrew J. Calder
BrainThe frontal lobes are necessary for `theory of mind'
657 Citations2001Donald T. Stuss
Frontal lobe lesions impaired the ability to infer mental states in others, with dissociation of performance within the frontal lobes, with some suggestion of a more important role for the right frontal lobe.
NeuronMind Blindness and the Brain in Autism
633 Citations2001Uta Frith
A circumscribed network that is active during mentalizing and links medial prefrontal regions with posterior superior temporal sulcus and temporal poles may involve weak connections between components of this system.
NeuroImageA PET Investigation of the Attribution of Intentions with a Nonverbal Task
632 Citations2000Éric Brunet-Gouet, Yves Sarfati +2 more
The data suggest that attribution of intentions to others is associated with a complex cerebral activity involving the right medial prefrontal cortex when a nonverbal task is used.
Psychological BulletinThe illusion of reality: A review and integration of psychological research on hallucinations.
609 Citations1990Richard P. Bentall
The available evidence suggests that hallucinations result from a failure of the metacognitive skills involved in discriminating between self-generated and external sources of information, and that different aspects of these skills are implicated in different types of hallucinations.
American Journal of PsychiatryBehavioral and Intellectual Markers for Schizophrenia in Apparently Healthy Male Adolescents
575 Citations1999Michael Davidson, Abraham Reichenberg +4 more
It is demonstrated that simple assessment tools can predict predisposition to schizophrenia in healthy male adolescents and the model's predictive ability does not change as a function of the time elapsed between testing and first hospitalization, suggesting that the model identifies apparently healthy individuals who will manifest the disease later who are not prodromal to psychosis.
Neuroreport‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome
574 Citations1996Francesca Happé, Stefan Ehlers +7 more
Five patients with Asperger syndrome with mild variant of autism with normal intellectual functioning were studied, and no task-related activity was found in this region of left medial prefrontal cortex, but normal activity was observed in immediately adjacent areas.
Psychological BulletinSocial cognition in schizophrenia.
569 Citations1997David L. Penn, Patrick W. Corrigan +3 more
The authors describe social cognition and differentiate it from nonsocial cognition and describe the potential implications of a social-cognitive model of schizophrenia for the etiology and development of the disorder.
Archives of General PsychiatryNeuronal and Glial Somal Size in the Prefrontal Cortex
533 Citations1998Grażyna Rajkowska, Lynn D. Selemon +1 more
Distinct cytometric abnormalities support the hypothesis that neuronal degeneration in the prefrontal cortex is not a prominent feature of the neuropathological changes in schizophrenia, although an ongoing process in Huntington disease.
Journal of Child Psychology and PsychiatryAttributing Social Meaning to Ambiguous Visual Stimuli in Higher‐functioning Autism and Asperger Syndrome: The Social Attribution Task
531 Citations2000Ami Klin
A social cognitive procedure the Social Attribution Task (SAT) is presented that reduces factors thought to facilitate ToM task performance without facilitating real-life social functioning.
Schizophrenia BulletinFacial Expressions of Emotions and Schizophrenia: A Review
520 Citations1998M. Mandal, Rakesh Pandey +1 more
A review of studies shows that schizophrenia patients, despite a general impairment of perception or expression of facial emotions, are highly sensitive to certain negative emotions of fear and anger.
Journal of Abnormal PsychologyEmotion perception in schizophrenia: Specific deficit or further evidence of generalized poor performance?
518 Citations1993Sandra Kerr, John M. Neale
Results suggested that differences between schizophrenics and normals on such tasks reflect a generalized performance deficit, rather than a specific emotion recognition deficit.
CognitionBeyond intuition and instinct blindness: toward an evolutionarily rigorous cognitive science
511 Citations1994Leda Cosmides, John Tooby
Cognitive psychology has an opportunity to turn itself into a theoretically rigorous discipline in which a powerful set of theories organize observations and suggest focused new hypotheses, but this cannot happen, as long as intuition and folk psychology continue to set the research agenda.
Journal of Cognitive NeuroscienceII. Hypersociability in Williams Syndrome
502 Citations2000Wendy Jones, Ursula Bellugi +5 more
Four studies measuring distinct aspects of hypersocial behavior in Williams syndrome are presented, each probing specific aspects in WMS infants, toddlers, school age children, and adults and promise to provide the ground-work for crossdisciplinary analyses of gene-brain-behavior relationships.
BMJChildhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11
484 Citations1994D.J. Done, Timothy J. Crow +2 more
Abnormalities of social adjustment are detectable in childhood in some people who develop psychotic illness, and sex and the rate of development of different components of the capacity for social interaction are important determinants of the risk of psychosis and other psychiatric disorders in adulthood.
NeuroreportModeling other minds
483 Citations1995Vinod Goel, Jordan Grafman +2 more
Nine normal volunteers performed a ‘theory of mind’ task while their regional brain blood flow pattern was recorded using the PET [15O]H2O technique, suggesting that when inferential reasoning depends on constructing a mental model about the beliefs and intentions of others, the participation of the prefrontal cortex is required.
Schizophrenia ResearchFacial affect recognition and information processing in schizophrenia and bipolar disorder
456 Citations1998Jean Addington, Donald Addington
It is suggested that for individuals with schizophrenia, deficits in facial affect recognition are stable deficits that are related to other impairments in neurocognition that have implications for psychosocial treatments.
The British Journal of PsychiatryRecognition of Mental State Terms
431 Citations1994Simon Baron‐Cohen, Howard Ring +4 more
This simple mental state recognition task appears to relate to theory of mind, in that both the orbito-frontal cortex and the frontal-polar region are impaired in autism.
Schizophrenia ResearchFacial affect and affective prosody recognition in first-episode schizophrenia
426 Citations2001Jane Edwards, Philippa Pattison +2 more
The detection of emotion recognition impairments in first-episode schizophrenia suggests a trait deficit, and the pattern of results is consistent with amygdala dysfunction in schizophrenia and related psychoses.
BrainFace processing impairments after amygdalotomy
399 Citations1995Andrew W. Young, John P. Aggleton +4 more
Archives of General PsychiatryReduced Dorsal and Orbital Prefrontal Gray Matter Volumes in Schizophrenia
372 Citations2000Raquel E. Gur, Patricia E. Cowell +6 more
Sch schizophrenia is associated with reduced gray matter volume in prefrontal cortex, which affects men and women in the dorsolateral sector and the effects are moderated by sex for dorsomedial and orbital regions and are related to symptom severity and cognitive function.
Journal of Cognitive NeuroscienceIs There a Social Module? Language, Face Processing, and Theory of Mind in Individuals with Williams Syndrome
372 Citations1995Annette Karmiloff‐Smith, Edward S. Klima +3 more
This work evaluates the details of this hypothesis through a series of experiments on language, face processing, and theory of mind carried out with subjects with Williams syndrome, a rare genetic neurodevelopmental disorder resulting in an uneven lin-guisticocognitive profile.
Biological PsychiatryMedial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder
361 Citations1997Godfrey D. Pearlson, Patrick E. Barta +8 more
Entorhinal cortex, not previously assessed using MRI in schizophrenia, was bilaterally smaller than normal in schizophrenia but not in bipolar disorder, and left anterior STG and right amygdala were smaller than predicted in schizophrenic but not bipolar disorder.
Journal of Abnormal PsychologyEmotion recognition and social competence in chronic schizophrenia.
350 Citations1996Kim T. Mueser, Robert Doonan +5 more
Chronicity of illness may contribute to face perception deficits in schizophrenia, which may affect social competence, and deficits in emotion recognition are related to poorer social competence.
Psychological MedicineTheory of mind impairments in schizophrenia: symptomatology, severity and specificity
339 Citations2001Graham Pickup, Chris Frith
There is a clear association between ToM impairment and behavioural signs in schizophrenia and toM impairments in schizophrenia are less severe than in autism, but are specific and not a reflection of general cognitive deficits.
Development and PsychopathologyCognitive and behavioral precursors of schizophrenia
313 Citations1999Barbara A. Cornblatt, M. Obuchowski +3 more
In PSP individuals impaired attention probably results from prenatal developmental abnormalities and is likely to be a marker of a biological vulnerability to schizophrenia, and attentional deficits are concluded to beA useful first step in screening for youngsters in need of early intervention.
Psychiatry Research NeuroimagingA differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics
301 Citations1999Mary L. Phillips, Lea M. Williams +6 more
The first evidence for a distinction between two schizophrenic patient subgroups on the basis of recognition of and neural response to different negative facial expressions is provided.
European Archives of Psychiatry and Clinical NeuroscienceFacial expression and emotional face recognition in schizophrenia and depression
296 Citations1992Wolfgang Gäebel, Wolfgang Wölwer
It was found that schizophrenics and depressives are characterized by different quantitative, qualitative, and temporal patterns of affect-related dysfunctions, and differences in patterns of Affect-related behavioral deficits may reflect Dysfunctions in different underlying psychobiological systems.
Psychological Medicine‘Theory of mind’ skills during an acute episode of psychosis and following recovery
293 Citations1998Val Drury, Emily Robinson +1 more
The results provide at best weak support for Frith's account and it remains unclear whether the ToM deficits demonstrated are genuine deficits or are a result of information-processing overload, but it is clear that difficulties interpreting interpersonal contexts, as shown by some schizophrenia patients, are state rather than trait characteristics.
American Journal of PsychiatryCognitive Neuropsychiatric Models of Persecutory Delusions
289 Citations2001Nigel Blackwood, Robert Howard +2 more
The major cognitive theories of persecutory delusion formation and maintenance are critically examined and the interaction of these cognitive processes, cross-sectionally and longitudinally, at cognitive psychological, neural network, and functional neuroanatomical levels are warranted to establish a comprehensive cognitive neuropsychiatric model of the persecutory delusions.
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280 Citations1998Gillian A. Doody, Mario E. Götz +3 more
Impaired theory of mind on second order tests is specific to schizophrenia when compared to mild learning disability and affective disorder control groups, and is relatively specific to particular psychopathological clusters in subjects with schizophrenia.
Archives of General PsychiatryVolumetric Measure of the Frontal and Temporal Lobe Regions in Schizophrenia
278 Citations2000Michael Sanfilipo, Todd Lafargue +7 more
The results suggest that gray matter deficits may be a fairly common structural abnormality of schizophrenia, whereas reductions in prefrontal white matter may be associated with schizophrenic negative symptoms.
BrainDissociation between `theory of mind' and executive functions in a patient with early left amygdala damage
264 Citations2001Cordelia Fine, Jim Lumsden +1 more
It is concluded that theory of mind is not simply a function of more general executive functions, and that executive functions can develop and function on-line, independently of theory ofMind.
Schizophrenia ResearchDifferential amygdala activation in schizophrenia during sadness
264 Citations1998Frank Schneider, U. Weiss +5 more
Functional magnetic resonance imaging was utilized to examine brain activity in subcortical and cortical regions of 13 medicated male schizophrenic patients and 13 matched healthy controls during happy and sad mood induction to provide new evidence of functional abnormalities in the limbic system.
Journal of Abnormal PsychologyCausal attributions in paranoia and depression: Internal, personal, and situational attributions for negative events.
263 Citations1997Peter Kinderman, Richard P. Bentall
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257 Citations2000Tamara Russell, Katya Rubia +7 more
This is the first functional MRI study to show a deficit in the left prefrontal cortex in schizophrenia during a socioemotional task, and it is suggested that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution.
American Journal of PsychiatryStructural abnormalities in deficit and nondeficit schizophrenia
255 Citations1993Robert W. Buchanan, Alan Breier +5 more
The results suggest that structural changes in the prefrontal region are not responsible for deficit symptoms, and the caudate, particularly the right caudates, may be associated with the production of these symptoms.
Psychiatry ResearchPositive and negative affect recognition in schizophrenia: a comparison with substance abuse and normal control subjects
254 Citations1997Morris D. Bell, Gary Bryson +1 more
These affect recognition deficits in schizophrenia are discussed as they relate to lateralization of brain function, high EE families, social skills impairment and implications for rehabilitation services.
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253 Citations2000Jean Addington, Donald Addington
Verbal ability, verbal memory and vigilance were significant predictors of social problem solving as assessed by the AIPSS, and the association between neurocognition and social functioning remains consistent over time.
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228 Citations2000Wouter Staal, Hilleke E. Hulshoff Pol +4 more
It is suggested that third ventricular enlargement, and to some extent cerebral volume decrease, may be related to genetic defects that produce a susceptibility to schizophrenia.
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218 Citations2001Monica Mazza, Alessandro De Risio +3 more
Significant differences are found between schizophrenics and normal controls in all ToM stories, with schizophrenic people performing worse than controls in first-order stories and among symptom dimensions.
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217 Citations1999Yves Sarfati, Marie‐Christine Hardy‐Baylé
The disorganization pattern in schizophrenia may be associated with a specific deficit of the cognitive ability referred to as theory of mind, and this deficit could be a state rather than a trait variable.
Psychiatry ResearchFacial emotion discrimination: III. Behavioral findings in schizophrenia
211 Citations1992Carolyn Heimberg, Raquel E. Gur +5 more
Performance of the emotion-discrimination tasks in the schizophrenic patients was impaired, relative to their performance of an age-discrimination task, and showed no difference between "happy" discrimination and "sad" discrimination.
Schizophrenia ResearchNeurocognitive and social functioning in schizophrenia: A 2.5 year follow-up study
209 Citations1997Jean Addington, Donald Addington
Acta NeuropathologicaRecent advances in defining the neuropathology of schizophrenia
205 Citations1996Steven E. Arnold, John Q. Trojanowski
Six broad areas of neuropathological investigation into schizophrenia are summarized and discussed and a general lack of neurodegenerative disease lesions or ongoing astrocytosis that would indicate post-maturational neural injury is found.
Journal of Autism and Developmental DisordersThe Awkward Moments Test: A Naturalistic Measure of Social Understanding in Autism
205 Citations2000Lisa Heavey, Wendy Phillips +2 more
A new advanced theory of mind task, developed to approximate the demands of real-life mentalizing in able individuals with autism, found adults with high-functioning autism and Asperger syndrome were most impaired in their ability to answer the questions requiring mind-reading ability.
Schizophrenia BulletinDeficits in Facial-affect Recognition and Schizophrenia
203 Citations1988R. L. Morrison, A. S. Bellack +1 more
Findings about facial-affect recognition in schizophrenia are reviewed and suggestions for future research emphasize careful consideration of affect-recognition deficits in relation to other parameters of schizophrenia.
Journal of Abnormal PsychologyMore evidence for generalized poor performance in facial emotion perception in schizophrenia.
197 Citations1996Jill E. Salem, Ann M. Kring +1 more
Results showed that medicated patients performed more poorly than controls overall; however, they performed no worse on facial emotion perception tasks than on a matched control task, which support Kerr and Neale's conclusion that schizophrenic patients do not have a differential deficit in facial emotion Perception ability.
Schizophrenia ResearchThe relationship of social cognition to ward behavior in chronic schizophrenia
194 Citations1996David L. Penn, Will Spaulding +2 more
Overall, there was a relationship between the measures of social cognition and behavior on the ward, and social cognition contributed unique variance beyond cognition to maladaptive behavior onThe ward.
Schizophrenia ResearchCerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia
187 Citations2001M.L. Paillère-Martinot, Anne Caclin +7 more
Findings emphasize a pattern of left-hemisphere gray matter abnormalities, and suggest that fronto-paralimbic connectivity may be altered in men with early onset schizophrenia.
Schizophrenia BulletinRisk Factors of Psychosis: Identifying Vulnerable Populations Premorbidly
186 Citations1996S. Serene Olin, Sarnoff A. Mednick
This article reviews premorbid indicators of psychosis that may be relevant to primary intervention and focuses on a specific study that assesses teacher ratings as predictors of psychosis in a high-risk population.
Psychological MedicineCognitive factors in source monitoring and auditory hallucinations
185 Citations1997Anthony P. Morrison, Gillian Haddock
These findings appear to be most consistent with theories proposing that hallucinations result from an external attributional bias for internal events.
NeuroreportAre face-responsive regions selective only for faces?
167 Citations1999Linda L. Chao, Alex Martin +1 more
Findings suggest that the neural representation of animals in the fusiform gyrus and the posterior STS relies strongly on the same neural substrates that represent faces.
Schizophrenia ResearchInvestigating theory of mind in schizophrenia: influence of verbalization in disorganized and non-disorganized patients
167 Citations1999Yves Sarfati, Marie-Christine Hardy-Baylé +2 more
Journal of Cognitive NeuroscienceReading the Windows to the Soul: Evidence of Domain-Specific Sparing in Williams Syndrome
165 Citations1998Helen Tager‐Flusberg, Jenea Boshart +1 more
This study tested the hypothesis that Williams syndrome, a rare genetic neurodevelopmental disorder with an unusual cognitive phenotype, involves spared abilities in the domain of understanding other minds and found evidence that mentalizing is a distinct cognitive domain.
American Journal of PsychiatryAnomalous Asymmetry of Fusiform and Parahippocampal Gyrus Gray Matter in Schizophrenia: A Postmortem Study
162 Citations2000Brendan McDonald, J. Robin Highley +5 more
The findings add substance to the view that the sex-related dimension of symmetry/asymmetry is integral to the disease process in schizophrenia and draw attention to the fusiform gyrus as a structure of particular interest in relation to disturbances of identification and naming in psychosis.
Psychiatry ResearchSocial perception in schizophrenia: the role of context
161 Citations2002David L. Penn, Mark Ritchie +3 more
Task performance for the group with schizophrenia/schizoaffective disorder was relatively independent of symptoms, but was related to social functioning in the treatment setting, and the ecological validity of these measures was examined.
Schizophrenia ResearchTheory of mind abilities of children with schizophrenia, children with autism, and normally developing children
155 Citations2000Tammy Pilowsky, Nurit Yirmiya +2 more
Overall, the group with autism passed significantly fewer tasks compared to the normally developing group, strengthening the notion of a limited understanding of ToM in schizophrenia and support the notion that ToM deficits, although more severe in autism, are not unique to autism.
Schizophrenia BulletinInterpersonal Problem Solving and Information Processing in Schizophrenia
147 Citations1995P. W. Corrigan, Rosemary Toomey
Significant and robust relationships were found between sensitivity to social cues and receiving, processing, and sending skills and Associations between problem solving and cognitive deficits did not seem to be attributable to psychiatric symptoms.
Journal of Abnormal PsychologyEmotion recognition in schizophrenia: Further investigation of generalized versus specific deficit models.
143 Citations2000David L. Penn, Dennis R. Combs +5 more
The authors examined the nature of emotion perception in schizophrenia and found that the acutely ill sample had a specific deficit in emotion perception that remained present after controlling for performance on the general perception tasks.
British Journal of Clinical PsychologySchizophrenic inability to judge facial emotion: A controlled study
138 Citations1989Sue Gessler, John Cutting +2 more
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135 Citations2000Benedicto Crespo‐Facorro, Jae‐Jin Kim +3 more
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133 Citations2001Antonio Convit, Oliver T. Wolf +7 more
A new method, which allows assessment of the superior, middle and inferior frontal gyrus, as well as the orbitofrontal and cingulate regions, and combines this with a geometric approach utilizing readily apparent anatomical landmarks is described.
Psychiatry ResearchSocial perception and social skill in schizophrenia
128 Citations1998Gail Hyronemus Ihnen, David L. Penn +2 more
Correlational analyses revealed that the self-ratings of social skill had the most consistent relationship with social skill among the social perception measures, even after controlling for symptomatology and subject demographics.
NeuroreportTime estimation in schizophrenia: an fMRI study at adjusted levels of difficulty
125 Citations2001Hans‐Peter Volz, Igor Nenadić +4 more
Although performing on the same level of individual difficulty, schizophrenia patients revealed less activations in prefrontal cortex and caudate nucleus, comparing time vs rest, and impairment in time estimation in schizophrenia might be mediated by specific fronto-thalamo-striatal dysfunction.
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125 Citations1997Yves Sarfati, Marie‐Christine Hardy‐Baylé +3 more
The results of this study confirm the principal hypothesis that schizophrenics with thought and language disorders have an impaired ability to attribute intentions and false beliefs as they figure in this experiment.
Schizophrenia BulletinCue Availability and Affect Perception in Schizophrenia
124 Citations1996Alan S. Bellack, Jack J. Blanchard +1 more
Investigation of affect perception in schizophrenia patients found that affect perception was not correlated with symptomatology or history of illness, and there were no gender differences.
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