Neural control of the pineal gland
Behavioural Brain ResearchPublished 1 December 1995
Robert Y. Moore
Citations380
SJR quartileQ2
SJR score0.92
SNIP0.77
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TL;DR
The rhythm in melatonin production by the mammalian pineal gland is generated by the circadian timing system, and the components of that system are described.
Abstract
The rhythm in melatonin production by the mammalian pineal gland is generated by the circadian timing system. The components of that system which mediate the function are: (1) visual projections through the retinohypothalamic tract to the circadian pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus; (2) the SCN which generates a circadian signal transmitted by SCN projections to the parvocellular autonomic component of the paraventricular nucleus; (3) paraventricular nucleus projections to the upper thoracic intermediolateral cell column; (4) preganglionic sympathetic fibers to the superior cervical ganglion; (5) postganglionic sympathetic fibers from the superior cervical ganglion to the pineal.
Keywords
MedicineNeuroscience
Endocrine ReviewsPineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
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Proceedings of the National Academy of SciencesPersistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.
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ScienceIndole Metabolism in the Pineal Gland: A Circadian Rhythm in <i>N</i> -Acetyltransferase
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Physiological ReviewsNeurophysiology of the suprachiasmatic circadian pacemaker in rodents
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Brain ResearchPineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus
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Cell and Tissue ResearchThe development, topographical relations and innervation of the epiphysis cerebri in the albino rat
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The innervation of the pineal body is examined in normal adult rats as well as in a number of specimens in which both superior cervical ganglia were removed, showing topographical relations with this organ.
Neuroscience LettersGABA is the principal neurotransmitter of the circadian system
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Brain ResearchThe course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord
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The Phaseolus lectin technique allowed the detection of the cells of origin in the paraventricular PVN, the precise position of two distinct descending axon pathways and the detailed morphology of terminal structures in midbrain, medulla oblongata and spinal cord.
Brain ResearchRetinohypothalamic projections in the hamster and rat demonstrated using cholera toxin
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The Journal of Comparative NeurologyThe afferent connections of the suprachiasmatic nucleus of the golden hamster with emphasis on the retinohypothalamic projection
397 Citations1982Gary E. Pickard
The afferent connections of the hypothalamic suprachiasmatic nucleus (SCN) of the golden hamster were examined using horseradish peroxidase (HRP) as the retrograde tracer molecule.
The Journal of Comparative NeurologyThe retinohypothalamic tract originates from a distinct subset of retinal ganglion cells
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The Journal of Clinical Endocrinology & MetabolismThe Durations of Human Melatonin Secretion and Sleep Respond to Changes in Daylength (Photoperiod)
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American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyIncrease in sympathetic outflow by paraventricular nucleus stimulation in awake rats
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The Journal of Clinical Endocrinology & MetabolismLight Exposure Induces Equivalent Phase Shifts of the Endogenous Circadian Rhythms of Circulating Plasma Melatonin and Core Body Temperature in Men*
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Journal of Biological RhythmsComparative Anatomy of the Mammalian Hypothalamic Suprachiasmatic Nucleus
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Journal of NeuroscienceSynaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron microscopy and synapsin I immunoreactivity
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Experimental Brain ResearchDescending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat
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The Journal of PhysiologyLocal inhibitory synaptic inputs to neurones of the paraventricular nucleus in slices of rat hypothalamus.
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Brain ResearchElectrical and metabolic activity of suprachiasmatic nucleus neurons in hamster hypothalamic slices
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Cell and Tissue ResearchSynapses of optic nerve afferents in the rat suprachiasmatic nucleus
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Brain Research BulletinLocalization of spinal cord preganglionic neurons innervating the superior cervical ganglion in the golden hamster
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Journal of Biological RhythmsAxon-Sparing Lesions of the Hypothalamic Paraventricular Nucleus Abolish Gonadal Responses to Photoperiod in Male Syrian Hamsters
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