The Mitotic Index of Human Bone Marrow in Healthy Individuals and Irradiated Human Beings
Generate an AI Snapshot to get a quick, structured summary of this paper.
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The mitotic index of the bone marrow of 7 healthy individuals was determined in Feulgen stained squash preparations to be 0.9% and it is possible to estimate the average turnover time of the red cell series and that of the white cell series to be in the order of 25 to 75 hours.
Abstract
The mitotic index of the bone marrow of 7 healthy individuals was determined in Feulgen stained squash preparations to be 0.9% for the time 10 a.m. to 1 p.m. The method did not allow the distinction of mitoses of different cell lineageg. On the basis of this mitotic index, it is possible to estimate the average turnover time of the red cell series to be in the order of 11 to 33 hours and that of the white cell series to be in the order of 25 to 75 hours. In serial studies the mitotic index of 8 patients, accidentally exposed to various doses of ionizing radiation, was followed over a period of 4.5 months. A dose dependence of the mitotic index was noticed on the fourth post-irradiation day. After 4 weeks, the number of mitotic figures was within normal limits. After 4.5 morths the values were significantly higher than normal. (auth)