Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats
Pharmacology Biochemistry and BehaviorPublished 1 February 1988
Anne O. Pfeffer, Herman H. Samson
Citations155
SJR quartileQ1
SJR score0.95
SNIP0.81
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TL;DR
Free feeding male Long Evans rats were trained to lever press on a Fixed Ratio 8 schedule for 10% ethanol reinforcement, and dopamine involvement in the mechanism of ethanol reinforcement was discussed in terms of dopamine involvement.
Abstract
Free feeding male Long Evans rats were trained to lever press on a Fixed Ratio 8 schedule for 10% ethanol reinforcement. Mean ethanol intake in 30-minute sessions was 0.38 g/kg. Subcutaneous apomorphine (APO: 0.025 to 0.5 mg/kg) and haloperidol (HAL: 0.005 to 0.0625 mg/kg) administered 15 minutes before sessions dose-dependently reduced responding, but only APO reduced momentary response rates. Low doses of HAL reduced the effect of 0.3 but not 0.05 mg/kg APO. When the rats were food-restricted, control response rates decreased, and APO (0.025 and 0.05 mg/kg) had no further effect. Results were discussed in terms of dopamine involvement in the mechanism of ethanol reinforcement.
Keywords
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