Effects of stress on methyltransferase synthesis: An important DNA repair enzyme.
Health PsychologyPublished 1 January 1985
Ronald Glaser, et al
Citations99
SJR quartileQ1
SJR score1.28
SNIP1.20
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TL;DR
The levels of methyltransferase, a DNA repair enzyme induced in response to carcinogen damage, were significantly lower in spleens from the stressed animals, suggesting that stress may impair DNA repair.
Abstract
The enhancement of tumor development following acute stress has been demonstrated in some animal studies. This study was designed to explore mechanisms that would account in part for the relationship between stress and tumor development at the level of DNA repair, using a rat model. Forty-four rats were given the carcinogen dimethylnitrosamine in their drinking water, and half were randomly assigned to a rotational stress condition. The levels of methyltransferase, a DNA repair enzyme induced in response to carcinogen damage, were significantly lower in spleens from the stressed animals. These data suggest that stress may impair DNA repair.
Keywords
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