A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones
Organic & Biomolecular ChemistryPublished 1 January 2003
Steven V. Ley, Ed Cleator, Peter R. Hewitt
Citations51
SJR quartileQ2
SJR score0.60
SNIP0.71
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TL;DR
A two-step selenocyclisation-oxidative deselenaton sequence was used to establish the 3a-hydroxy-pyrrolo[2,3-b]indole core and these tricycles were used as effective precursors to 10b-Hydroxy-pyrazino[1',2':1,5]pyrrole-1,4-diones.
Abstract
A two-step selenocyclisation-oxidative deselenaton sequence was used to establish the 3a-hydroxy-pyrrolo[2,3-b]indole core; these tricycles were used as effective precursors to 10b-hydroxy-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-diones.
Keywords
ChemistryMaterials SciencePharmacology, Toxicology and Pharmaceutics
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