The 'Preclinical Phase' of Probable Alzheimer's Disease
Archives of NeurologyPublished 1 May 1995
Richard T. Linn
Citations434
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Findings support previous contentions that a "preclinical phase" of detectable cognitive deficits can precede the clinical diagnosis of probable AD by many years, and support the hypothesis that problems with secondary verbal memory are among the first signs of AD.
Abstract
These findings support previous contentions that a "preclinical phase" of detectable cognitive deficits can precede the clinical diagnosis of probable AD by many years, and they also support the hypothesis that problems with secondary verbal memory are among the first signs of AD.
Keywords
Medicine
Encyclopedia of Social WorkDiagnostic and Statistical Manual of Mental Disorders
109,983 Citations2013Janet B. W. Williams, Michael B. First
Journal of Psychiatric Research“Mini-mental state”
86,858 Citations1975Marshal F. Folstein, Susan E. Folstein +1 more
A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
NeurologyClinical diagnosis of Alzheimer's disease
27,993 Citations1984Guy M. McKhann, David A. Drachman +4 more
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Psychological ReviewThe magical number seven, plus or minus two: Some limits on our capacity for processing information.
17,276 Citations1994George Miller
About some experiments that tested how accurately people can assign numbers to the magnitudes of various aspects of a stimulus, and since the results are analyzed in terms of the concepts of information theory, I shall have to preface my discussion with a few remarks about this theory.
The Journal of PsychologyA Standardized Memory Scale for Clinical Use
2,935 Citations1945David Wechsler
NeurologyPrevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study
531 Citations1992David Bachman, Philip A. Wolf +6 more
Prevalence of dementia and orobable SDAT were greater for women than men and increased with advancing age, and the fema1e:male ratio of prevalence for cohort members 75 years of age and older was 1.8 for all cases of Alzheimer type dementia and 2.7 for cases of probable SDAT.
NeurologyIncidence of dementia and probable Alzheimer's disease in a general population
468 Citations1993David Bachman, Philip A. Wolf +6 more
In a general population sample, incidence of dementia and of probable AD did not level off with age and was not different in men and women.
Annals of NeurologyDevelopment of dementing illnesses in an 80‐year‐old volunteer cohort
452 Citations1989Robert Katzman, M. Aronson +8 more
It is possible to identify a large cohort of 80‐year‐olds who are at low risk for AD and a smaller cohort at very high risk, prospectively followed over a 5‐year period.
NeurologyWomen, myocardial infarction, and dementia in the very old
258 Citations1990M. K. Aronson, Wee Lock Ooi +7 more
A new finding is that history of myocardial infarction (MI) is associated with dementia, such that women with a history of MI were 5 times more prone to dementia than those without a history, which was not true for men.
Archives of NeurologyVery Mild Senile Dementia of the Alzheimer Type
251 Citations1989Martha Storandt
Consideration of premorbid individual differences in psychological functions will probably be required if psychometric test performances are to be effective in detecting SDAT in the very mild stage.
Archives of NeurologyVery Mild Senile Dementia of the Alzheimer Type
198 Citations1989Eugene H. Rubin
Results suggest that the CDR 0.5 stage likely represents the incipient clinical manifestation of Alzheimer's disease and that the majority of subjects with CDR 1.5 have "very mild senile dementia of the Alzheimer type."
Journal of the American Geriatrics SocietyDementia of the Alzheimer Type
112 Citations1986Jeffrey L. Cummings, D. Frank Benson
The Inventory includes aphasia, amnesia, abnormal cognition and visuospatial skills, inappropriate lack of concern, and normal motor functions, and can facilitate recognition of treatable illnesses masquerading as DAT.
Psychological ReportsNEUROPSYCHOLOGICAL TEST PERFORMANCE IN FRAMINGHAM: A DESCRIPTIVE STUDY
74 Citations1987Mary E. Farmer, Lon R. White +7 more
CortexDifferential Effects of Age and Cerebral Atrophy Upon Span of Immediate Recall and Paired-Associate Learning in Older Patients Suspected of Dementia
64 Citations1979Alfred W. Kaszniak, David C. Garron +1 more
Results of analyses of variance indicate that Digit-Span is affected by cerebral atrophy but not by age, while Paired-Associate Learning is affectedBy both age and cerebral atroph.
AGEReflections of biological changes in the psychological performance of the aged
32 Citations1980Asenath LaRue, Lissy F. Jarvik