Prefrontal–posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations
Biological PsychiatryPublished 30 December 2002
Javier Quintana, Tiffany Wong, Elena Ortiz-Portillo, Edward Kovalik, Tom Davidson, Stephen R. Marder
Citations124
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
It is hypothesized that a primarily dysfunctional PFC in schizophrenia might show hypofrontality or hyperfrontality as a result, respectively, of efficient or inefficient PPC compensation, as dictated by task demands, and biased the demands of WM tasks toward anticipating responses or remembering cues.
Abstract
In schizophrenia, a PFC dysfunction results in hypo- or hyperfrontality as a function of whether other alternate areas of a PFC-PPC network for WM are available and efficacious in supporting specific task demands.
Keywords
MedicineNeuroscience
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Archives of General PsychiatryStructural Magnetic Resonance Imaging Abnormalities in Men With Severe Chronic Schizophrenia and an Early Age at Clinical Onset
95 Citations1997Laura Marsh
Data from this unique sample of severely ill schizophrenic men emphasize a pattern of structural abnormalities involving the cortex, but not the hippocampus, in schizophrenia, and support theories suggesting that superior temporal gyrus abnormalities contribute selectively to psychotic symptoms and that the extent of structural irregularities is unrelated to age of clinical symptom onset.
Brain Research ReviewsThe limbic cortex in schizophrenia: focus on the anterior cingulate
94 Citations2000Carol A. Tamminga
Schizophrenia ResearchDifferential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder
89 Citations2001Tilo Kircher, Edward T Bulimore +5 more
The attenuated engagement of right temporal cortex, which is implicated in language comprehension at the discourse level, is consistent with neuropsychological evidence linking thought disorder with deficits in processing linguistic context.
NeuroreportAbnormal functional lateralization of the sensorimotor cortex in patients with schizophrenia
86 Citations1997Venkata S. Mattay, Joseph H. Callicott +6 more
Patients with schizophrenia were unable to recruit as focal a response to a simple, automatic sequential finger movement task, and showed greater ipsilateral activation in the primary sensorimotor and lateral premotor regions and had a significantly lower laterality quotient than normal subjects.
Biological PsychiatryLevels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients
80 Citations2000Boris P. Sokolov, Andrew Tcherepanov +2 more
That similar abnormalities were found for mRNAs encoding different synaptic vesicle and synaptic plasma membrane proteins suggests that they reflect overall neurodevelopmental abnormalities in synaptic connectivity in the temporal cortex of schizophrenic patients rather than changes in the number of synaptic vESicles per synapse or abnormalities in a specific synaptic function.
SynapseDifferential distribution of tyrosine hydroxylase fibers on small and large neurons in layer II of anterior cingulate cortex of schizophrenic brain
79 Citations1997Francine M. Beneš, Mark S. Todtenkopf +1 more
The findings reported here are consistent with a model of schizophrenia in which a subtle “miswiring” of ventral tegmental inputs may result in a relative, though not absolute, hyperdopaminergic state with respect to an impaired population of GABAergic interneurons.
Neurobiology of Learning and MemoryDistributed Memory for Both Short and Long Term
77 Citations1998Joaquı́n M. Fuster
Electrophysiology and neuroimaging indicate that working memory, like long-term memory, is a widely distributed function, largely neocortical, and neuropsychology points to the wide distribution of cortical memory networks.
Human Brain MappingNeural basis of novel and well-learned recognition memory in schizophrenia: A positron emission tomography study
75 Citations2001Benedicto Crespo‐Facorro, Anne K. Wiser +5 more
It is suggested that different neural pathways are engaged during novel recognition memory in patients with schizophrenia compared to healthy individuals and between‐ and within‐group differences.
Schizophrenia ResearchProton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia
69 Citations1997Raymond F. Deicken, Ling Zhou +2 more
The NAA findings provide support for either neuronal dysfunction or neuronal loss in the anterior cingulate region in schizophrenia and the absence of choline signal elevation does not support accelerated turnover of membrane phospholipids which might be expected if there were ongoing neuronal atrophy or neuronal necrosis.
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