National Cooperative Gallstone Study
GastroenterologyPublished 1 April 1982
John J. Albers, Scott M. Grundy, Patricia A. Cleary, Donald Small, John M. Lachin, Leslie J. Schoenfield
Citations74
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
Subjects in the National Cooperative Gallstone Study undergoing 12 mo of therapy with chenodeoxycholic acid for the dissolution of gallstones had a mean increase in serum cholesterol of 20mg/dl as compared with a 5 mg/dl increase in the placebo group.
Abstract
Subjects in the NationalCooperative Gallstone Study undergoing 12 mo of therapy with chenodeoxycholic acid for the dissolution of gallstones (Jowdose, 375 mglday, n = 252; high-dose, 750 mglday, n = 253) had a mean increase in serum cholesterol of 20 mgldl as compared with a 5 mgldl increase in the placebo group [n = 258).The effect of chenodeoxycholic acid on lipoproteins was determined in a random subset of the high-dose (n = 136) and placebo (n = 143) groups.For men, the mean baseline adjusted estimated low-density lipoprotein cholesterol level at 12 mo was significantly higher in the high-dose group than in the placebo group (159 vs. 148 mgldl, p < O.fJl), whereas among women this difference was not demonstrated.Change in Jowdensity lipoprotein cholesterol level was inversely
Keywords
Medicine
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