Variation in FTO contributes to childhood obesity and severe adult obesity
Nature GeneticsPublished 13 May 2007
Christian Dina, Stephen Eyre, Sophie Gallina, Emmanuelle Durand, Antje Körner, Peter Jacobson
Citations1,613
SJR quartileQ1
SJR score16.59
SNIP6.64
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TL;DR
It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Abstract
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Keywords
Biochemistry, Genetics and Molecular Biology
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