Neopterin as a marker for activated cell-mediated immunity: Application in HIV infection
Immunology TodayPublished 1 May 1988
Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, Ernst R. Werner, Manfred P. Dierich, Helmut Wächter
Citations567
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TL;DR
Neopterin studies reveal that preactivation of cell-mediated immunity is associated with poor prognosis in cancer patients and in human immunodeficiency virus infection, neopterin levels increase in parallel with progressive disease, are inversely correlated with CD4 + /CD8 + T-cell subset ratios and are of predictive significance.
Abstract
The production of neopterin is closely correlated with activation of cell-mediated immunity. The increased neopterin concentrations appear to be produced by human macrophages specifically stimulated with gamma-interferon. As Helmut Wachter and colleagues review here, neopterin studies reveal that preactivation of cell-mediated immunity is associated with poor prognosis in cancer patients. In addition, in human immunodeficiency virus (HIV) infection, neopterin levels increase in parallel with progressive disease, are inversely correlated with CD4+/CD8+ T-cell subset ratios and are of predictive significance.
Keywords
Immunology and MicrobiologyMedicine
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