Effect of tamoxifen on lipid peroxide and antioxidative system in postmenopausal women with breast cancer
CancerPublished 1 July 1994Open access
Muthusamy Thangaraju, Thiruvengadam Vijayalakshimi, Panchanatham Sachdanandam
Citations60
SJR quartileQ1
SJR score2.95
SNIP1.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The purpose of this study was to understand the rate of lipid peroxidation and the status of antioxidants in tamoxifen‐treated postmenopausal women with breast cancer.
Abstract
The results suggest that tamoxifen therapy exerts significant positive effects on the rate of lipid peroxidation and protective systems in postmenopausal women with breast cancer.
Keywords
ChemistryMedicine
Journal of Biological ChemistryThe Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
9,003 Citations1972Hara P. Misra, Irwin Fridovich
It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
ScienceSelenium: Biochemical Role as a Component of Glutathione Peroxidase
7,769 Citations1973John T. Rotruck, A. L. Pope +4 more
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Analytical BiochemistryColorimetric assay of catalase
5,441 Citations1972Asru K. Sinha
A simple colorimetric assay for catalase activity has been described using K2Cr2O7/acetic acid reagent to determine values of different enzyme sources and compared with the values obtained by titrimetric methods.
ScienceDietary Carcinogens and Anticarcinogens
2,986 Citations1983Bruce N. Ames
Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
Methods in enzymology on CD-ROM/Methods in enzymology[51] Assays for differentiation of glutathione S-Transferases
2,413 Citations1981William H. Habig, William B. Jakoby
This chapter provides the spectrophotometric, titrimetric, nitrite, and cyanide assay for the differentiation of glutathione S-transferases.
The LancetSystemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy
2,189 Citations1992Early Breast Cancer Trialist's Collaborative Group
Biochemical MedicineA simple fluorometric assay for lipoperoxide in blood plasma
2,105 Citations1976Kunio Yagi
Chemistry and Physics of LipidsLipid peroxides and human diseases
1,322 Citations1987Kunio Yagi
A method to determine the lipid peroxide level in human serum or plasma and its profile of change in several human diseases is described and Intervention of lipid peroxides in the pathogenesis of certain diseases is also mentioned.
Analytical ChemistryFluorometric Determination of Selenium in Biological Material with 2,3-Diaminonaphthalene.
674 Citations1966J. H. Walkinson
Journal of Biological ChemistryGlycoproteins of Cell Surfaces
557 Citations1971Hartmut Glossmann, David M. Neville
Each membrane is found to have an identifiable glycoprotein subunit pattern composed of at least 6 to 11 different sized subunits, and most of the staining intensity is present in one to three subunits.
PubMedAn improved colorimetric enzymatic assay of ceruloplasmin.
469 Citations1961Herbert A. Ravin
An improved colorimetric enzymatic assay of ceruloplasmin is described in detail, providing an optimal combination of technical simplicity with precision and reliability of results.
PubMedInhibition of protein kinase C by tamoxifen.
468 Citations1985C A O'Brian, Rob M. J. Liskamp +2 more
These findings suggest that the growth-inhibitory and cytotoxic effects of tamoxifen, which have been observed at microM concentrations of the drug, may be in part due to its effects on protein kinase C.
Endocrine ReviewsEndocrine Pharmacology of Antiestrogens as Antitumor Agents*
403 Citations1990V. Craig Jordan, Catherine S. Murphy
The focus of clinical application slowly changed from the broad market of contraception to the relatively small market of advanced breast cancer therapy.
Journal of Biological ChemistryThe Effect of Carbon and Nitrogen Sources on the Level of Metabolic Intermediates in Escherichia coli
353 Citations1971O. H. Lowry, J. Carter +2 more
Measurements of the level of metabolic intermediates in acetate-grown cells, before and after the addition of glucose, suggest that isocitrate lyase is controlled in vivo by metabolites other than phosphoenolpyruvate, and that both isocite lyase and isOCitrate dehydrogenase play roles in regulating isocItrate utilization.
FEBS LettersEstrogens as natural antioxidants of membrane phospholipid peroxidation
327 Citations1987Katsuaki Sugioka, Yasuko Shimosegawa +1 more
Estrogens, such as estrone, estradiol and estriol, were tested as possible antioxidants of lipid peroxidation induced by Fe3+‐ADP‐adriamycin or Fe3 +‐ ADP‐ascorbate.
British Journal of PharmacologyA current view of tamoxifen for the treatment and prevention of breast cancer
301 Citations1993V. Craig Jordan
Although there are individual requests by patients for tamoxifen to prevent breast cancer, individual treatment is inappropriate and tamoxIFen can only be adequately evaluated as a preventive in randomized, double-blind clinical trials.
Biochemical and Biophysical Research CommunicationsTamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase
293 Citations1984Hing-Yat Peter Lam
Evidence is presented that tamoxifen is an antagonist of calmodulin, a major cellular calcium receptor and calcium dependent regulator of many cellular processes and inhibited the activation of phosphodiesterase by Calmodulin.
AGEFree radical theory of aging: The “free radical” diseases
189 Citations1984Denham Harman
Dietary intervention in the “free radical” diseases can reasonably be expected to decrease the period of senescence and to increase by 5 or more years the span of healthy productive life.
PubMedDifferential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen.
169 Citations1985Roger R. Reddel, Leigh C. Murphy +2 more
It is confirmed that ER-positive breast cancer cells are more sensitive than ER-negative breast cells to the growth-inhibitory effects of tamoxifen and it is demonstrated that, in all ER- positive cells, growth inhibition and cytotoxicity are accompanied by characteristic changes in cell cycle kinetic parameters.
ScienceThe Control of Oxidant Stress at Fertilization
152 Citations1991Bennett M. Shapiro
The sea urchin egg uses an oxidative cross-linking reaction that requires hydrogen peroxide and a secreted peroxidase and thus faces the challenge of oxidant stress at the beginning of its development.
Advances in free radical biology and medicineRelationship between oxygen metabolism, aging and development
152 Citations1986Rajindar S. Sohal, Robert G. Allen
It is postulated that a shift in redox potential may play a role in the modulation of gene activity during development and aging, and is most demonstrable in organisms with a variable basal metabolic rate, such as poikilotherms and mammalian hibernators.
Biochemical JournalStudies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour
130 Citations1986Kevin H. Cheeseman, M. W. Collins +5 more
The substantial increase in alpha-tocopherol relative both to total lipid and to methylene-interrupted double bonds in fatty acids is the major contributor to lipid-soluble chain-breaking antioxidant in lipid extracts of normal liver and of Novikoff tumour material.
CancerRisk of breast cancer among greek women in relation to nutrient intake
126 Citations1988Klea Katsouyanni, D. Trichopoulos +6 more
Cases reported significantly less frequent consumption of vitamin A after controlling for total caloric intake, potential external confounding variables and other nutrients associated with breast cancer risk, and there was no evidence that high intake of dietary fat increases the risk of breast cancer.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismGrowth-related lipid peroxidation in tumour microsomal membranes and mitochondria
102 Citations1979Gianna Maria Bartoli, Tommaso Galeotti
It is suggested that the low susceptibility of tumour membranes to peroxidative agents may be a factor responsible for the high mitotic activity of this tissue.
British Journal of CancerSerum vitamin E and subsequent risk of cancer
98 Citations1987NJ Wald, SG Thompson +3 more
The most likely explanation for these results is that the low vitamin E levels observed in subjects who were diagnosed as having cancer before the elapse of one year from the date of blood collection were a metabolic consequence, rather than a precursor, of the cancer.
JNCI Journal of the National Cancer InstituteBreast Cancer in Premenopausal and Postmenopausal Women2
98 Citations1974Kathleen M. Stavraky, Susan Emmons
Among the prememopausal women, increased breast cancer was associated with early menarche, and among oral contraceptive users, there was a trend toward greater risk with increasing age at 1st use of OCs.
Breast Cancer Research and TreatmentLaboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications
97 Citations1983V. Craig Jordan, C. Chem
The data strongly support the use of long-term (up to five-year) adjuvant therapy with tamoxifen in patients as a suppressive therapy for homone-sensitive metastases.
CancerEffect of tamoxifen on plasma lipids and lipoproteins in postmenopausal women with breast cancer
88 Citations1994Muthusamy Thangaraju, K. Suresh Kumar +2 more
The purpose of the study was to evaluate the effects of tamoxifen on plasma lipid and lipoprotein profiles in postmenopausal Indian women who were disease‐free after primary treatment for breast cancer.
FEBS LettersThe antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation
77 Citations1990Helen Wiseman, Miranda J. Laughton +3 more
The anti‐oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes and its cis isomer and N‐desmethyl form are weaker inhibitors, but 4‐hydroxytamoxifens is much more powerful.
PubMedTamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.
42 Citations1992Jong Shiaw Lim, Krystyna Frenkel +1 more
It is reported that TAM (5 microM) totally inhibits hydrogen peroxide (H2O2) formation by 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-treated human neutrophils, and may suppress the dietary fat-induced HMU in the same manner at it does in TPA-induced neutrophil.
Journal of Laboratory and Clinical MedicineA critical study of the Carr-Price reaction for the determination of β-carotene and vitamin A in biological materials
19 Citations1943Margaret M. Käser, Jakob A. Stekol
The applicability of the Carr-Price reaction to the analysis of biological materials has been critically re-examined using the Evelyn photoelectric colorimeter using excellent recoveries of crystalline β-carotene and vitamin A with reproducible results.