Disposition of Morphine in Man

SciencePublished 22 October 1971

Sydney Spector, Elliott S. Vesell

DOI10.1126/science.174.4007.421

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Citations65

SJR quartileQ1

SJR score10.42

SNIP6.62

TL;DR

The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study.

Abstract

The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.

Keywords

MedicinePharmacology, Toxicology and Pharmaceutics

Journal of Clinical InvestigationGenetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man

224 Citations1969Elliot S. Veseli, John G. Page

The results suggest that some inducing agents may be used to minimize individual variations in drug metabolism where such variations create therapeutic problems by exposing patients who slowly metabolize certain drugs to toxicity and other patients who rapidly metabolize some drugs to undertreatment.

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ScienceGenetic Control of Drug Levels in Man: Antipyrine

221 Citations1968Elliot S. Vesell, John G. Page

Individuals with identical genotypes exhibited significantly less variability in antipyrine halflife than did genetically different individuals (dizygotic twins), therefore variations in antipyrsine metabolism appear to be determined genetically rather than environmentally.

ScienceMorphine: Radioimmunoassay

212 Citations1970Sydney Spector, Charles W. Parker

The development of a radioimmunoassay for morphine is described, where the hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule.

ScienceGenetic Control of Drug Levels in Man: Phenylbutazone

177 Citations1968Elliot S. Vesell, John G. Page

The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

Journal of Clinical InvestigationGenetic control of dicumarol levels in man

153 Citations1968Elliot S. Vesell, John G. Page

Risks of toxicity on the one hand and of failure to anticoagulate adequately on the other can be reduced by determining dicumarol half-life before starting long-term therapy, as well as in unrelated volunteers administered progressively larger doses at 10-day intervals.

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Journal of Pharmacology and Experimental TherapeuticsQUANTITATIVE DETERMINATION OF MORPHINE IN SERUM BY RADIOIMMUNOASSAY

118 Citations1971Sydney Spector

Evidence is presented for the formation of antibodies with specificity for the alkaloid as demonstrated by precipitin reaction and by binding of dihydromorphine-8H by the antisera.

Clinical Pharmacology & TherapeuticsComparison of the nalorphine test and urinary analysis in the detection of narcotic use

27 Citations1964Henry W. Elliott, Norman Nomof +3 more

The pupillary test is a useful method of screening for narcotic use, which might well be combined with chemical tests for narcotics in the urine.

NatureTolerance to Drugs, especially to Morphine

7 Citations1960Guy Nadeau, Georges Sobolewski

This work has shown that as tolerance develops in the rat, the amount of morphine appearing in the urine decreases, and it becomes imperative to look to other explanations for the mechanisms of development of these phenomena.