Heat shock proteins: the missing link between hormonal and reproductive factors and rheumatoid arthritis?
Annals of the Rheumatic DiseasesPublished 1 October 1991Open access
José António Pereira da Silva
Citations11
SJR quartileQ1
SJR score5.73
SNIP4.44
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TL;DR
It has been hypothesized that hormonal contraceptive use and pregnancy elicit the production of higher amounts of endogenous heat shock proteins, which induce immunotolerance to subsequent exposure to the actual triggering agent of rheumatoid arthritis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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524 Citations1985M.G. Catelli, Nadine Binart +5 more
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It is concluded that autoimmune arthritis is probably caused by antigenic cross-reactivity, and an autoimmune disease may be triggered by structural mimicry between antigens in the environment and self-antigen in the individual.
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American Journal of EpidemiologyTHE EPIDEMIOLOGY OF RHEUMATOID ARTHRITIS IN ROCHESTER MINNESOTA: A STUDY OF INCIDENCE, PREVALENCE, AND MORTALITY1
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A study of the incidence and prevalence of rheumatoid arthritis conducted in Rochester, MN, during the period 1950 through 1974 revealed an average annual incidence rate of 28.1 per 100,000 population for males and of 65.7 per100,000 for females, which could be inferred that oral contraceptives and postmenopausal estrogens are likely causes.
Proceedings of the National Academy of SciencesHuman major histocompatibility complex contains genes for the major heat shock protein HSP70.
335 Citations1989Carole A. Sargent, Ian Dunham +2 more
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304 Citations1988PieterC.M. Res, F. C. Breedveld +5 more
A 65 kD-protein-specific reactivity of synovial T cells, mainly present in an early stage of joint inflammation, may be responsible for triggering chronic arthritis.
ScienceAn Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis
285 Citations1986Stephen E. Kurtz, J M Rossi +2 more
A strikingly similar pattern of expression occurs during oogenesis in Drosophila, suggesting that it may be one of the earliest developmental pathways to evolve in eukaryotic cells.
The LancetT LYMPHOCYTES OF RHEUMATOID ARTHRITIS PATIENTS SHOW AUGMENTED REACTIVITY TO A FRACTION OF MYCOBACTERIA CROSS-REACTIVE WITH CARTILAGE
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The observation that the three groups did not differ in their responses to streptococci and a T-cell mitogen indicates that reactivity of the RA patients to the mycobacterial fraction was specific, raising the possibility that bacterial antigens cross-reactive with cartilage proteoglycans may be relevant to the pathogenesis of RA.
ContraceptionOral contraceptives, cigarette smoking and other factors in relation to arthritis
247 Citations1987Martin Vessey, L Villard‐Mackintosh +1 more
There was no important association between oral contraceptive use and other forms of arthritis and an unexpected finding was a strong association between referral to hospital for rheumatoid arthritis and cigarette smoking.
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243 Citations1988T W McMullin, Richard L. Hallberg
It is shown that a Tetrahymena thermophila 58-kilodalton mitochondrial protein (hsp58) displayed antigenic similarity with mitochondrially associated proteins from Saccharomyces cerevisiae, Xenopus laevis, Zea mays, and human cells, and found to share several other characteristics with hsp58, including heat inducibility and the property of associating into distinct oligomeric complexes.
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240 Citations1989Anne M. VanBuskirk, B L Crump +2 more
It appears that characteristics of the heat shock proteins are shared by a protein playing a role in antigen presentation, suggesting some commonality in function.
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212 Citations1989Maries van den Broek, Els J. M. Hogervorst +4 more
It is reported that streptococcal cell wall-induced arthritis in rats, a T cell-dependent chronic, erosive polyarthritis, can be prevented by pretreatment of the rats with the mycobacterial 65-kD heat shock protein.
Journal of Cellular BiochemistryTransformation of glucocorticoid and progesterone receptors to the DNA‐binding state
188 Citations1987William B. Pratt
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187 Citations1990M. E. J. Billingham, Stephen Carney +2 more
The r65- kD protein appears to produce an antigen-specific protection against arthritis induced by bacterial cell walls containing the 65-kD protein, suggesting that protection occurs by preventing clonal proliferation of autoreactive T lymphocytes that are induced by the adjuvant properties of mycobacterial cell walls.
Proceedings of the National Academy of SciencesMitogen and lymphokine stimulation of heat shock proteins in T lymphocytes.
166 Citations1988Douglas K. Ferris, Annick Harel‐Bellan +3 more
Two distinct members of the ancient family of heat shock genes, HSP70 and HSP90, are shown to be stimulated at the activation and progression stages of lymphocyte mitogenesis, which suggests that genetic mechanisms evolved from primitive stress/adaptation responses may be conserved in mammalian cellular activation.
Molecular and Cellular BiologyA highly evolutionarily conserved mitochondrial protein is structurally related to the protein encoded by the Escherichia coli groEL gene.
162 Citations1988T W McMullin, Richard L. Hallberg
The LancetORAL CONTRACEPTIVES AND RHEUMATOID ARTHRITIS: FURTHER EVIDENCE FOR A PREVENTIVE EFFECT
160 Citations1982Jan P. Vandenbroucke, J. Boersma +5 more
Findings confirm the finding from the Royal College of General Practitioners Oral Contraceptive Study that the incidence rate of rheumatoid arthritis among OC users was halved.
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158 Citations1988Seiji Minota, Shigeo Koyasu +2 more
A previously unrecognized autoantibody to the 90,000-D heat-shock protein, hsp90, a molecule thought to have important functions in the cellular response to stress, virus-induced transformation, steroid hormone receptor action, and cellular activation is reported here.
Arthritis & RheumatismThe pill, parity, and rheumatoid arthritis
150 Citations1990Tim D. Spector, Eve Roman +1 more
It is suggested that pregnancy and OCP use have a "protective effect" on the development of RA, although the mechanism remains unclear.
Annals of the Rheumatic DiseasesRaised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.
135 Citations1989Georgia Tsoulfa, G.A.W. Rook +6 more
The rises in IgG and IgA antibodies to the 65 kD protein in RA were significantly higher than in the other diseases, however, it is interesting that this protein is the one responsible for adjuvant arthritis in the rat.
Proceedings of the National Academy of SciencesTherapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure.
128 Citations1987Ofer Lider, N Karin +2 more
It is reported that T lymphocytes, otherwise incapable of triggering an immune response, can be transformed into effective immunogens by treating the cells in vitro with hydrostatic pressure, and this results demonstrate that effector T lymphocyte suitably treated may serve as agents for specifically controlling the immune system.
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119 Citations1988Lutz B. Giebel, Bernd P. Dworniczak +1 more
Hsc70 RNA is very abundant in F9 stem cells and brain, but very little is found in 14-day-old embryos, suggesting that the uncoating activity of coated vesicles may not be the only function of hsc70 protein.
JAMANoncontraceptive Hormones and Rheumatoid Arthritis in Perimenopausal and Postmenopausal Women
113 Citations1986Jan P. Vandenbroucke
The use of noncontraceptive hormones before onset of joint disease was compared between 490 perimenopausal and postmenopausal women with rheumatoid arthritis and a control group of 659 women with soft-tissue r heumatologic disorders and/or osteoarthritis and a negative association was found.
Arthritis & RheumatismStress proteins, arthritis, and autoimmunity
112 Citations1989John B. Winfield
The data at hand are sufficiently compelling, however, to suggest that vaccination against T cells that recognize stress proteins may eventually become part of the therapeutic armamentarium to prevent or cure some forms of arthritis.
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112 Citations1986Deborah Abrams Kaplan
Ninety-six women with rheumatoid arthritis (RA) were found to have an abortion ratio higher than that of a comparison group (p = 0.005), which suggests the presence of a "rheumatoids diathesis" which long antedates the expression of the disease.
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100 Citations1989Hua Xiao, John T. Lis
Annals of the Rheumatic DiseasesSubfertility before and after the Development of Rheumatoid Arthritis in Women
92 Citations1965April Kay, Francis Bach
A controlled study was undertaken of fertility and related factors in women before and after the development of their rheumatoid arthritis.
Lara D. VeekenHUMAN ZYGAPOPHYSEAL JOINT CAPSULE AND SYNOVIAL FOLD INNERVATION
86 Citations1987L GILES, James R. Taylor
Small myelinated nerves course through the synovial folds, not in association with blood-vessels, suggesting that these nerves are nociceptive and, therefore, may have clinical significance in spinal pain.
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79 Citations1983A Unger, April Kay +2 more
The results suggest that this protein may play an important part in inducing the remissions of rheumatoid arthritis which frequently occur during pregnancy.
Arthritis & RheumatismStress‐induced proteins in chondrocytes from patients with osteoarthritis
69 Citations1985Toshikazu Kubo, Christine A. Towle +2 more
Journal of Biological ChemistryChick heat-shock protein of Mr = 90,000, free or released from progesterone receptor, is in a dimeric form
60 Citations1989Christine Radanyi, Jack‐Michel Renoir +2 more
Direct evidence is brought direct evidence that both free hsp 90 and the non-hormone binding hSp 90 component released from the nontransformed steroid receptor in the cytosol are in a dimeric form.
EndocrinologyEstrogenic Regulation of Uterine 90-Kilodalton Heat Shock Protein *
58 Citations1988Chidambaram Ramachandran, M.G. Catelli +2 more
It is reported that ovariectomy reduces the uterine concentration of hsp-90, and estradiol causes a time-dependent increase in uterine hSp-90 as early as 4 h after steroid administration, reaching a maximum increase of 4-fold between 18-24 h.
Annals of the Rheumatic DiseasesIs poor pregnancy outcome a risk factor in rheumatoid arthritis?
55 Citations1990Tim D. Spector, Alan J. Silman
It was not possible to confirm that prior poor reproductive outcome is a risk factor in rheumatoid arthritis, although hormonal and gynaecological factors are undoubtedly important in the aetiology of RA.
Annals of the Rheumatic DiseasesAdverse reproductive outcomes in women who subsequently develop rheumatoid arthritis.
51 Citations1988Alan J. Silman, Eve Roman +2 more
All the perinatal deaths occurred before clinical disease onset in the women with RA, and it is possible that in these two groups of women with a similar genetic backgroundPerinatal loss may be related, at least in part, to disease expression.
Journal of Biological ChemistrySteroid hormone regulation of the gene encoding the chicken heat shock protein hsp 108.
45 Citations1987M Baez, David R. Sargan +5 more
The hsp 108 gene codes for an interesting new eucaryotic heat shock protein which is regulated also by steroid hormones in a tissue-specific manner and nuclear "run-off" assays indicate that the gene is regulated both at the transcriptional level and by mRNA stabilization.
Scandinavian Journal of RheumatologyDo Oral Contraceptives Reduce the Incidence of Rheumatoid Arthritis?:<i>A Pilot Study Using the Stockholm County Medical Information System</i>
45 Citations1984Peter Allebeck, Anders Ahlbom +2 more
The Stockholm County medical information system was used to select cases for a pilot study on the association between oral contraceptive use and the incidence of rheumatoid arthritis, and the findings are compatible with the hypothesis that the use of OCs is associated with a reduced incidence of RA.
Annals of the Rheumatic DiseasesThe heat shock protein response and its role in inflammatory disease.
36 Citations1990V R Winrow, Lachy McLean +2 more
This treatise aims at summarising knowledge of the characterisation, cellular distribution, and function of HSPs, and their possible role in inflammation with specific reference to rheumatology.
GenomeExpression of the small heat shock genes during <i>Drosophila</i> development: comparison of the accumulation of hsp23 and hsp27 mRNAs and polypeptides
35 Citations1989Daniel Pauli, André‐Patrick Arrigo +3 more
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31 Citations1989Tim D. Spector, Marc C. Hochberg
Results show that OCPs may not have a protective effect on the development of RA, but rather may prevent the progression from mild to severe disease by modifying the disease process, thus the potential disease-modifying effects of sex hormones in patients with incipient RA should be examined.
Annals of the Rheumatic DiseasesIs pregnancy a risk factor in the causation of rheumatoid arthritis?
28 Citations1986Alan J. Silman
Pregnancy is associated with remission of the disease in the last trimester, which frequently relapses after delivery, which may be explained by the large rise in female sex hormone concentration and the subsequent fall postnatally.
Journal of Cellular PhysiologyHSP70‐related proteins in bovine skeletal muscle
24 Citations1989Vince Guerriero, Deborah A. Raynes +1 more
The lower molecular form of HSP70 was not present in fetal tissue but was detectable in newborn animals, suggesting that the levels are regulated during development.
Molecular and Cellular BiologyHeat Shock and Developmental Regulation of the <i>Drosophila melanogaster hsp83</i> Gene
23 Citations1989Hua Xiao, John T. Lis
Biochemical and Biophysical Research CommunicationsSequence analysis of the nonsteroid binding component of the calf uterine estrogen receptor
21 Citations1988Thomas Ratajczak, Martine J. Brockway +3 more
Lara D. VeekenPreliminary Findings from a Case-Control Study of the Risk of Rheumatoid Arthritis in Relation to Oral Contraceptive use
19 Citations1989Thomas D. Koepsell, Carin E. Dugowson +9 more
DevelopmentThe developmental expression of the heat-shock response in <i>Xenopus laevis</i>
19 Citations1989R. Davis, Mary Lou King
Xenopus defolliculated oocytes displayed a highly variable response to heat shock depending on the culture medium, and it is shown that Xenopus hsps have different solubilities perhaps reflecting their different subcellular locations.
ContraceptionThe relationships of SHBG with current and previous use of oral contraceptives and oestrogen replacement therapy
18 Citations1989Timothy J. Key, Malcolm C. Pike +5 more
Both premenopausal and postmenopausal women who had previously used OCs had a lower mean SHBG concentration than never users of OCs and current users of oral contraceptives and of oestrogen replacement therapy had higher meanSHBG values than non-current users.
Biochemistry and Cell BiologyThe 90 000 dalton heat shock protein, a lot of smoke but no function as yet
16 Citations1989Britta Denise Hardesty, Gisela Kramer
The synthesis of some, but not all, hsp 90 species is strongly induced by heat shock and other forms of environmental stress, which leads to its classification as one of the major heat shock proteins.
EndocrinologyRegulation of Heat Shock Protein Synthesis by Gonadotropins in Cultured Granulosa Cells*
16 Citations1989Avri Ben‐Ze'ev, Abraham Amsterdam
Results support the notion that hsp90 plays a role in the control of steroid hormone action and in vitro translation assays and Northern blot analyses suggest that hSp90 synthesis in gonadotropin-stimulated cells may be regulated by mRNA translational efficiency.
Human ReproductionRU486 (an anti-steroid hormone) receptor structure and heat shock protein mol. wt 90 000 (hsp 90)
13 Citations1988Etienne‐Emile Baulieu
A new parameter is proposed for explaining both anti-progesterone and anti-glucocorticosteroid activities of RU486, a synthetic derivative of high receptor affinity that caps the DNA binding site of the receptor and would prevent it from binding to the DNA of hormone regulatory elements (HRE) and modifying transcription of regulated genes.
The LancetPOOR REPRODUCTIVE OUTCOME IN INSULIN-DEPENDENT DIABETIC WOMEN ASSOCIATED WITH LATER DEVELOPMENT OF OTHER ENDOCRINE DISORDERS IN THE MOTHERS
13 Citations1984Valerie Beral, Eve Roman +1 more
Differences in birthweight and mortality could not be explained by the severity of the mothers' diabetes at the time of their pregnancies, and were evident even before the diabetes was diagnosed.
Lara D. VeekenOral Contraceptives and the Risk of Rheumatoid Arthritis: The Great Transatlantic Divide?
13 Citations1989Jan P. Vandenbroucke, Johanna M W Hazes +2 more
Lara D. VeekenOral Contraceptives, Replacement Oestrogens and the Risk of Rheumatoid Arthritis
9 Citations1989M. Harnandez-Avila, M H Liang +7 more
Scandinavian Journal of ImmunologyAutoantibodies from Rheumatoid Arthritis Patients Recognize Antigens on the Synoviocyte Surface
8 Citations1988B. T. Pérez-Maceda, Carmelo Bernabéu +3 more
This autoreactivity against synovial cells in RA supports the idea that these cells participate in the initial immune response of the disease.
ContraceptionPlasma protein binding of norethisterone
8 Citations1982Viveca Odlind, Arne Victor +1 more
The binding of NET to SHBG was studied in five women during a 21-day treatment cycle with an oral contraceptive containing 3 mg NET-acetate and 50 microgram ethinylestradiol, indicating that the total concentrations of NET measured by radioimmunoassay only in part reflect the biologically active fraction of the steroid.
Lara D. VeekenOral Contraceptives and Rheumatoid Arthritis; Further Evidence for a Protective Effect Independent of Duration of Pill use
6 Citations1989J. M. W. Hazes, Ben A. C. Dijkmans +3 more
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6 Citations1989Christopher R. Neal, N G Read +2 more
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ImmunologyImmune tolerance and autoimmunity
3 Citations1985Hans Wigzell
This chapter describes immune tolerance as a specific lack of immune reactivity against one particular antigen while retaining normal reactions against all other immunogens at the level of the lymphocytes and may comprise various lymphocyte groups but not necessarily all types of lymphocytes.