Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia
GastroenterologyPublished 1 July 1987
Mark Feldman, Lawrence R. Schiller, John H. Walsh, John S. Fordtran, Charles T. Richardson
Citations37
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
The intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin is reported.
Abstract
The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.
Keywords
Medicine
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