Interaction of 1,4-dihydropyridines with somatic Ca currents in hippocampal CA1 neurones of the guinea pig in vitro
Neuroscience LettersPublished 1 September 1986
R. J. Docherty, David A. Brown
Citations67
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
The results demonstrate that Ca channels in hippocampal CA1 neurones possess a dihydropyridine receptor in common with Ca channels with similar characteristics to those in other tissues.
Abstract
Two distinct Ca currents may be recorded from guinea pig hippocampal CA1 neuronal somata: a non-inactivating (persistent) current and a rapidly inactivating (transient) current. Nimodipine, a 'calcium antagonist', reduced both Ca currents though the transient current was somewhat less sensitive than the persistent current. BAY K 8644, a 'calcium agonist' enhanced the persistent current and shifted the activation threshold for this current to more negative potentials. BAY K 8644 also enhanced the transient Ca current though the effect was very variable. The results demonstrate that Ca channels in hippocampal CA1 neurones possess a dihydropyridine receptor in common with Ca channels in other tissues.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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