Contrast's effect on spatial summation by macaque V1 neurons
Nature NeurosciencePublished 1 August 1999
Michael P. Sceniak, Dario L. Ringach, Michael J. Hawken, Robert Shapley
Citations633
SJR quartileQ1
SJR score11.20
SNIP4.70
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TL;DR
It is found that the extent of spatial summation in macaque V1 neurons depended on contrast, and was on average 2.3-fold greater at low contrast.
Abstract
Stimulation outside the receptive field of a primary visual cortical (V1) neuron reveals intracortical neural interactions. However, previous investigators implicitly or explicitly considered the extent of cortical spatial summation and, therefore, the size of the classical receptive field to be fixed and independent of stimulus characteristics or of surrounding context. On the contrary, we found that the extent of spatial summation in macaque V1 neurons depended on contrast, and was on average 2.3-fold greater at low contrast. This adaptive increase in spatial summation at low contrast was seen in cells throughout V1 and was independent of surround inhibition.
Keywords
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The Journal of PhysiologyThe contrast sensitivity of retinal ganglion cells of the cat
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Spatial summation within cat retinal receptive fields was studied by recording from optic‐tract fibres the responses of ganglion cells to grating patterns whose luminance perpendicular to the bars varied sinusoidally about the mean level.
Annual Review of NeuroscienceStimulus Specific Responses from Beyond the Classical Receptive Field: Neurophysiological Mechanisms for Local-Global Comparisons in Visual Neurons
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The historical development of the evidence of response selectivity for visual stimuli presented beyond the CRF is traced; the anatomical pathways that sub serve these far-reaching surround mechanisms are examined; and the possible relationships between these mechanisms and perception are explored.
NeuronImprovement in visual sensitivity by changes in local context: Parallel studies in human observers and in V1 of alert monkeys
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The contextual sensitivity of human contrast thresholds and of superficial layer complex cells in monkey V1 was measured and it was shown that 42% of complex cells demonstrated facilitation for a second bar outside their classical receptive fields with a similar dependency on relative location and orientation.
Journal of NeuroscienceContextual Modulation in Primary Visual Cortex
890 Citations1996Karl Zipser, Victor A. F. Lamme +1 more
Vision ResearchQuantitative analysis of cat retinal ganglion cell response to visual stimuli
764 Citations1965R.W. Rodieck
The concept of superposition has been found to be a useful and powerful one to apply to retinal function and an equation which enables calculations of responses to a wide range of visual stimuli is derived.
NatureVisual input evokes transient and strong shunting inhibition in visual cortical neurons
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The model accurately predicted responses to drifting grating stimuli of various contrasts, orientations, and spatiotemporal frequencies as well as fitting and interpreting physiological data.
NatureVisual cortical mechanisms detecting focal orientation discontinuities
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The basic laminar organization of excitatory local circuitry in the primary visual cortex of the macaque monkey is similar to that described previously in the cat's visual cortex, but within this basic framework is a more complex organization.
NatureCollinear stimuli regulate visual responses depending on cell's contrast threshold
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It is shown that neuronal facilitation preferentially occurs when a near-threshold stimulus inside the receptive field is flanked by higher-contrast, collinear elements located in surrounding regions of visual space.
Medical & Biological Engineering & ComputingGlass-coated platinum-plated tungsten microelectrodes
597 Citations1972E. G. Merrill, A.Jerald Ainsworth
A novel technique is described for the removal of insulation from electrode tips by embedding them in a softened bead of solder glass, producing clean fractures of the borosilicate glass at the surface of the bead; the bare, undamaged tip of the electrode is then withdrawn.
Proceedings of the National Academy of SciencesSynaptic background activity influences spatiotemporal integration in single pyramidal cells.
530 Citations1991Öjvind Bernander, Rodney J. Douglas +2 more
The electrical behavior of an anatomically reconstructed layer V cortical pyramidal cell receiving input from 4000 excitatory and 1000 inhibitory cells firing spontaneously at 0-7 Hz significantly changes the response of the cell to temporal desynchronized versus temporal synchronized synaptic input distributed throughout the neuron.
Journal of NeurophysiologyContrast gain control in the cat's visual system
528 Citations1985Izumi Ohzawa, G. Sclar +1 more
The idea that the adaptation of cortical neurons to local contrast levels in a visual stimulus is functionally advantageous is examined, and contrast-response functions of cells in striate cortex are measured while systematically adapting them to different contrast levels of stimulus gratings.
NatureContrast dependence of contextual effects in primate visual cortex
514 Citations1997Jonathan B. Levitt, Jennifer S. Lund
The way that single neurons integrate information across the visual field depends not only on the precise form of stimuli at different locations, but also crucially on their relative contrasts, which reflect a complex gaincontrol mechanism that regulates cortical neuron responsiveness.
Journal of NeurophysiologyLength and width tuning of neurons in the cat's primary visual cortex
487 Citations1994Gregory C. DeAngelis, Ralph D. Freeman +1 more
Results show that end- and side-inhibition tend to be strongest at the orientation and spatial frequency that yield maximal excitation, suggesting that inhibition is mediated by a pool of neurons.
Visual NeuroscienceRole of Inhibition in the Specification of Orientation Selectivity of Cells in the Cat Striate Cortex
481 Citations1989A. B. Bonds
Mechanisms supporting orientation selectivity of cat striate cortical cells were studied by stimulation with two superimposed sine-wave gratings of different orientations, revealing that the reduction of the base response by the mask usually did not vary regularly with mask orientation, although response facilitation from the mask was orientation selective.
Brain ResearchOrientation-selective inhibition from beyond the classic visual receptive field
404 Citations1978J. I. Nelson, B.J. Frost
The ability to elicit an orientationselective inhibitory effect from beyond the classic receptive field limits strongly suggests an intracortical origin for the inhibitory input.
Vision ResearchThe unresponsive regions of visual cortical receptive fields
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Around the classical receptive field (regions within which a moving or flashing bar can elicit a response from a cell) there are large regions which dramatically influence the cell's responsiveness, which are facilitatory and inhibitory regions of the receptive field.
Journal of NeuroscienceSynaptic Integration in Striate Cortical Simple Cells
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The results suggest that intracortical inhibition is the dominant, and perhaps sole, mechanism of suppression in the simple receptive field, and the inhibitory influences operated within a wide dynamic range.
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317 Citations1997Alex M. Thomson
Properties of local synaptic connections in neocortex, studied with dual intracellular recordings in vitro and correlated with cell and synaptic morphology are summarized, showing frequency-dependent, incrementing facilitation at higher presynaptic frequencies.
Proceedings of the National Academy of SciencesDynamic changes in receptive-field size in cat primary visual cortex.
303 Citations1992Mark W. Pettet, Charles D. Gilbert
The findings support the idea that even in adult animals RFs are dynamic, capable of being altered by the sensory context, and propose that the expansion may account for visual illusions, such as perceptual fill-in of stabilized images and illusory contours.
The Journal of PhysiologyActivity‐dependent properties of synaptic transmission at two classes of connections made by rat neocortical pyramidal axons <i>in vitro</i>
275 Citations1997Alex M. Thomson
If synapse location allowed significant depolarization of one active site by another, voltage‐dependent enhancement could produce supralinear EPSP summation and overcome PPD, and profound frequency‐dependent facilitation was seen at fifteen connections involving two classes of postsynaptic inter neurones.
Journal of NeuroscienceLaminar organization and contrast sensitivity of direction-selective cells in the striate cortex of the Old World monkey
230 Citations1988MJ Hawken, Andrew Parker +1 more
The findings suggest that the directionally selective cells may fall into at least 2 distinct populations, which may be the first stages in the visual pathway that correspond to those channels, inferred from psychophysical experiments, that underlie the detection of movement.
Experimental Brain ResearchCharacteristics of surround inhibition in cat area 17
225 Citations1997Frank Sengpiel, Arjune Sen +1 more
Inhibition by orientations flanking the optimum could serve to sharpen orientation selectivity in the presence of contextual stimuli and to enhance orientational contrast; and it may play a part in orientation contrast illusions.
Cerebral CortexA local circuit approach to understanding integration of long-range inputs in primary visual cortex
197 Citations1998David C. Somers
This work supports the notion that receptive field integration is the result of local processing within small groups of neurons rather than in single neurons, and construction of self-contained modules that capture nonlinear local circuit interactions are constructed.
The Journal of Comparative NeurologyAnatomical organization of primate visual cortex area VII
171 Citations1981Jewell Lund, Anita E. Hendrickson +2 more
The Golgi Rapid and Kopsch techniques have been used to provide material for an examination of the internal neuronal organization of cortical area VII of the Macaca monkey and are hoped that this anatomical survey will provide a better foundation for physiological explorations of the region.
Proceedings of the National Academy of SciencesReceptive field structure in the visual cortex: does selective stimulation induce plasticity?
82 Citations1995Gregory C. DeAngelis, Akiyuki Anzai +2 more
It is reported that there is no change in either the size or the internal structure of the receptive field following several minutes of surround stimulation, suggesting that dynamic alterations of receptive field structure do not underlie short-term plasticity in the mature primary visual cortex.
Journal of Physiology-ParisRedistribution of synaptic efficacy: A mechanism to generate infinite synaptic input diversity from a homogenous population of neurons without changing absolute synaptic efficacies
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Since the change in synaptic transmission associated with RSE depends on the history of action potential activity it is concluded that RSE serves as a mechanism to generate a potentially infinite diversity of synaptic input.