Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
Annals of NeurologyPublished 31 December 2001
Yoshio Momose, Miho Murata, Kazuhiro Kobayashi, Masaji Tachikawa, Yuko Nakabayashi, Ichiro Kanazawa
Citations198
SJR quartileQ1
SJR score3.74
SNIP2.26
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TL;DR
The results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease and confirm an association with the S18Y polymorphism of the UCH‐L1 gene.
Abstract
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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