Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy
Experimental Brain ResearchPublished 1 February 1985
Michael W. Oliver, James J. Miller
Citations124
SJR quartileQ3
SJR score0.64
SNIP0.80
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TL;DR
Enhancement of the late Cl--insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.
Abstract
In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl(-)-dependent and a late (200 ms-8 s) Cl(-)-independent inhibition were shown to be present in the dentate. Enhancement of the late Cl(-)-insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.
Keywords
MedicineNeuroscience
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