The genetic lesions of autoimmunity.
PubMedPublished 1 March 1980Open access
N. R. Rose, Yi Kong, R. A. Sundick
Citations39
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Social SciencesMedicine
The LancetCOOPERATING AND CONTROLLING FUNCTIONS OF THYMUS-DERIVED LYMPHOCYTES IN RELATION TO AUTOIMMUNITY
537 Citations1971A. C. Allison, A. M. Denman +1 more
Evidence is presented that T cells can exert specific feedback control of autoantibody formation and relaxation of T-cell control in ageing humans and experimental animals may be an important contributory factor in the development of autoimmunity.
ScienceAutoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type
405 Citations1971A O Vladutiu, Noel R. Rose
Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.
The Journal of Experimental MedicineInduction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide.
174 Citations1977Patricio Esquivel, N R Rose +1 more
The administration of soluble mouse thyroglobulin in conjunction with bacterial lipopolysaccharide (LPS) led to the termination of natural tolerance to MTg in mice and the involvement of T cells in LPS-treated mice was suspected, suggesting the presence of self-reactive T cells.
The LancetLYMPHOCYTES BINDING HUMAN THYROGLOBULIN IN HEALTHY PEOPLE AND ITS RELEVANCE TO TOLERANCE FOR AUTOANTIGENS
164 Citations1973A.D. Bankhurst, Giorgio Torrigiani +1 more
Lymphocytes of eleven normal subjects were studied with autoradiographic techniques for the presence of cells which bind human 125 I-thyroglobulin (Tg) and identified primarily as B lymphocytes in four patients by their marked or complete depletion after passage through this column.
The Journal of ImmunologyRegulation of Autoimmune Response to Mouse Thyroglobulin: Influence of <i>H-2D</i>-end Genes
142 Citations1979Yi‐chi M. Kong, Chella S. David +3 more
Findings demonstrate genetic interaction between I-region and D-end gene products in the response to a self-antigen, MTg.
The Journal of ImmunologyMurine Thyroiditis: Importance of Adjuvant and Mouse Strain for the Induction of Thyroid Lesions
136 Citations1971Noel R. Rose, Frank J. Twarog +1 more
A mouse comparison of two preparations of complete Freund's adjuvant showed that one, using n-hexadecane and glycerol mono-oleate with freshly harvested tubercle bacilli, was more effective in eliciting both dermal hypersensitivity and thyroid lesions than a mixture of paraffin oil and mannide mono-olesate with dried tuberclebacilli.
PubMedRecent observations and concepts in immunological unresponsiveness and autoimmunity.
134 Citations1971Weigle Wo
Clinical Immunology and ImmunopathologyThe Obese strain (OS) of chickens: An animal model with spontaneous autoimmune thyroiditis
103 Citations1974Georg Wick, Roy S. Sundick +1 more
PubMedAutoimmune murine thyroiditis. IV. Localization of genetic control of the immune response.
100 Citations1974Vesna J. Tomazic, Noel R. Rose +1 more
The immune response to mouse thyroglobulin in mice is associated with the centromeric (left) side of the H-2 region, and antibody formation is less strongly influenced by this major gene and may involve additional genetic or non-genetic factors.
Cellular ImmunologyCellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice
89 Citations1975A O Vladutiu, N. R. Rose
Cell transfer experiments were performed to determine the role of T and B lymphocytes in the genetic control of autoimmune thyroiditis and found that adult thymectomized mice had a markedly decreased immune response to thyroglobulin.
PubMedSpontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.
81 Citations1970Georg Wick, Joseph H. Kite +1 more
The Journal of ImmunologyNeonatal Thymectomy Increases Spontaneous Autoimmune Thyroiditis
59 Citations1973Peter Welch, Noel R. Rose +1 more
EndocrinologyAbnormal Thyroid Regulation in Chickens with Autoimmune Thyroiditis*
43 Citations1979Roy S. Sundick, Nandalal Bagchi +3 more
The obese strain of chicken (OS) in which virtually all individuals spontaneously develop autoimmune thyroiditis was developed by selection from the Cornell strain (CS), under conditions in which TSH secretion is minimized is examined.
The Journal of ImmunologyIncreased Iodine Uptake by Obese Strain Thyroid Glands Transplanted to Normal Chick Embryos
41 Citations1976Roy S. Sundick, Georg Wick
Results, along with a previous report, suggest that an abnormality of the thyroid gland might be an important factor in the development of autoimmune thyroiditis.
Cellular ImmunologyEvidence for thyroglobulin-reactive T cells in good responder mice
30 Citations1978Patricio Esquivel, Yi-chi M. Kong +1 more
Evidence is provided for the presence of MTg-reactive T cells in good responder mice as well as the effectiveness of poly A:U as adjuvant in promoting antibodies to MTg in poor responder B10.D2 mice.
Proceedings of the National Academy of SciencesInfluence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens.
27 Citations1979L D Bacon, N. R. Rose
Three partially inbred substrains of Obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis and the influence of the major histocompatibility complex (B haplotype) was marked in one, less marked but still significant in a second, and barely detectable and transient in a third.
Proceedings of the National Academy of SciencesAbnormal response to minor histocompatibility antigens in Obese strain chickens.
23 Citations1976Marek Jakóbisiak, Roy S. Sundick +2 more
A dramatic difference between the Obese and the normal Cornell strain (the strain from which Obese was derived) was detected when both were thymectomized and grafted at hatching, suggesting the presence of an abnormalThymus or thymus-derived suppressor T cells in Obese strain chickens.
PubMedThe influence of thymectomy on the development of erythrocyte-specific antinuclear factors in obese strain (OS) and normal white leghorn chickens.
15 Citations1973Boris Albini, Georg Wick
While thymectomized OS chickens show the highest titres, those of thymected NWL birds are in the same range as in untreated OS chickens, and in ovo bursectomy suppresses the development of EANF.
Immunological CommunicationsThe Macrophage Disappearance Reaction (MDR) as an in Vivo Test of Delayed Hypersensitivity in Mice
8 Citations1977Vesna J. Tomazic, Pierluigi E. Bigazzi +1 more
It is demonstrated that the MDR represents a specific and quantitative method for detecting the delayed type of cellular immune response in mice and developed a higher degree of delayed hypersensitivity than the group immunized with MTE.