Degradation of mucopolysaccharides by hepatic lysosomes
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TL;DR
The activity of hepatic mucopolysaccharase (hyaluronate glycanohydrolase, EC 3.2.35) was related to the turnover rate of liver connective tissue and the enzyme activity was increased in reversible fibrosis and greatly diminished in irreversible fibrosis.
Abstract
1. Hepatic lysosomes degraded highly polymerized mucopolysaccharides. The degradation products as shown by high-voltage electrophoresis were tetra- and oligosaccharides, indicating the presence of endohexosaminidase in the liver. 2. The role of bacterial contamination, and non-specific oxido-reductive degradation of mucopolysaccharides were excluded. 3. The activity of hepatic mucopolysaccharase (hyaluronate glycanohydrolase, EC 3.2.1.35) was related to the turnover rate of hepatic connective tissue. The enzyme activity was increased in reversible fibrosis and greatly diminished in irreversible fibrosis.