Combined ventilatory and breath-holding evaluation of sensitivity to respiratory gases
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TL;DR
Comparison of experimentally determined responses to various combinations of O2 and CO2 tensions agree quite well with those predicted and indicate that oxygen plays a small but definite role in the regulation of eupnic breathing at sea level.
Abstract
Direct measurements of the ventilatory response to variations in CO 2 tension independent of changes in O 2 tension are easily obtained by breathing mixtures of carbon dioxide in 100% oxygen. Direct determination of the respiratory response to O 2 , however, is not possible due to alternations in CO 2 tension resulting from changes in ventilation. Therefore, an attempt has been made to determine this response empirically by a combined analysis of breath-holding and ventilatory data. Comparison of experimentally determined responses to various combinations of O 2 and CO 2 tensions agree quite well with those predicted by this approach and indicate that oxygen plays a small but definite role in the regulation of eupnic breathing at sea level. Submitted on October 22, 1958