BONE GROWTH FACTORS
Orthopedic Clinics of North AmericaPublished 1 July 2000
Safdar N. Khan, Mathias P. Bostrom, Joseph M. Lane
Citations139
SJR quartileQ2
SJR score0.69
SNIP1.01
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TL;DR
Growth factors including bone morphogenetic proteins, transforming growth factor beta, platelet-derived growth factor, insulin-like growth factors I and II, and acidic and basic fibroblast growth factors are powerful tools for fracture healing and bone grafting.
Abstract
Osteoblastic culture models, experimental, and clinical models have revealed that bone growth factors influence cellular activity. Growth factors including bone morphogenetic proteins, transforming growth factor beta, platelet-derived growth factor, insulin-like growth factors I and II, and acidic and basic fibroblast growth factors, are powerful tools for fracture healing and bone grafting. Understanding the role that bone growth factors play in bone repair is necessary to apply these factors in a clinical setting.
Keywords
Medicine
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66 Citations1992James E. Carpenter, John A. Hipp +4 more
There was no significant correlation between the biomechanical properties at the sites of the osteotomies and the levels of serum insulin-like growth-factor I and Administration of growth hormone had no measurable effect on fracture-healing in this model of normal animals.
Biochemical and Biophysical Research CommunicationsPlatelet-Derived Growth Factor (PDGF)-BB Stimulates Osteoclastic Bone Resorption Directly: The Role of Receptor β
61 Citations1998Zhongmin Zhang, Jianting Chen +1 more
The results suggest that PDGF-BB promotes adult osteoclastic bone resorption directly through PDGF receptor beta and is believed to play important roles in the bone healing process and reconstruction.
Journal of Dental ResearchContinuous Administration of Basic Fibroblast Growth Factor (FGF-2) Accelerates Bone Induction on Rat Calvaria— An Application of a New Drug Delivery System
59 Citations1998T. Kimoto, Ryuji Hosokawa +4 more
It is concluded that continuous slow administration of a small amount of FGF-2 accelerates bone-derived osteogenic cytokine-induced new bone formation and thereby enhances bone regeneration at a fracture site.
BoneCharacterization of mitogenic activities extracted from bovine bone matrix
58 Citations1986Thomas A. Linkhart, John C. Jennings +3 more
The mitogenic activity in the unfractionated mixture of proteins released from adult bovine bone matrix during demineralization with ethylenediaminetetraacetate has been examined and suggests that combinations of bone derived and systemic factors can coordinately stimulate bone cell proliferation.
Acta Orthopaedica ScandinavicaExogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit
56 Citations1995Yvette S. Bland, Matthew A. Critchlow +1 more
In conclusion, the application of FGF-1 or F GF-2 to normally healing fractures of the rabbit tibia does not have a significant effect on the rate of healing.
BoneIncreased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone
52 Citations1990B. Bak, Peter Holmberg Jørgensen +1 more
Ultimate load, stiffness, and energy absorption of the intact Bones increased in the b-hGH injected animals, but no differences were found in ultimate stress values or normalized energy, indicating that the changes in the intact bones were quantitative phenomena.
Journal of Bone and Joint Surgery - British VolumeA biomechanical study of the effects of growth hormone in experimental fracture healing
52 Citations1980MD Northmore-Ball, M B Wood +1 more
No evidence was found that growth hormone given alone could produce an overall shortening of the healing time in fresh fractures, but a significant increase in torque index was found in the two-week group of test animals but not in subsequent groups.
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