Clinical pharmacology and therapeutics
Postgraduate Medical JournalPublished 1 August 1990Open access
G C Fenn
Citations483
SJR quartileQ2
SJR score0.79
SNIP1.05
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TL;DR
It seems likely (though unproven) that normalization of the gastric mucosa will reduce the likelihood of gastric ulcer complications and this aspect of the use of misoprostol would appear to be scientifically justified.
Keywords
MedicineEconomics, Econometrics and Finance
GastroenterologyToward an Epidemiology of Gastropathy Associated With Nonsteroidal Antiinflammatory Drug Use
391 Citations1989James F. Fries, Stephen R. Miller +4 more
It is estimated that the syndrome of NSAID-associated gastropathy can be estimated to account for at least 2600 deaths and 20,000 hospitalizations each year in patients with rheumatoid arthritis alone.
GastroenterologyDouble-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum
137 Citations1988Frank L. Lanza, Richard L. Aspinall +4 more
It is concluded that misoprostol is highly effective and significantly better than cimetidine in protecting the gastric mucosa from tolmetin-induced injury; however, both agents were highly protective in the duodenum.
Archives of Internal MedicineMisoprostol Heals Gastroduodenal Injury in Patients With Rheumatoid Arthritis Receiving Aspirin
130 Citations1989S. Roth
Misoprostol, coadministered with aspirin, is well tolerated and highly effective in healing aspirin-associated gastroduodenal lesions in patients with rheumatoid arthritis without altering the therapeutic benefits of aspirin.
Postgraduate Medical JournalClinical pharmacology and therapeutics
86 Citations1990M. J. Kendall, Richard Horton
Some areas of therapeutics are chosen where the advances in knowledge made by the specialist should be presented to the non-specialist with the suggestion that his or her therapeutic approach may need to undergo a little reconsideration, including areas such as adverse reactions, interactions, pharmacokinetics and toxicology.
PubMedA blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration.
85 Citations1988François Lanza, K. Peace +3 more
It is found that misoprostol protects the gastric and duodenal mucosae against ulceration seen with the administration of both aspirin and the nonsteroidal antiinflammatory drug tolmetin and its cytoprotective properties with those of sucralfate are compared for the first time.
QJMGastrointestinal Events in Patients Prescribed Non-steroidal Anti-inflammatory Drugs: A Controlled Study Using Record Linkage in Tayside
77 Citations1989P.H.G. Beardon, Sheila V. Brown +1 more
Analyzing the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and gastrointestinal events in Tayside revealed that NSAID takers were more likely to develop disease of theintestinal system and symptoms involving the gastrointestinal system.
GastroenterologyMisoprostol Reduces Gastroduodenal Injury From One Week of Aspirin: An Endoscopic Study
64 Citations1989Geoffrey C. Jiranek, Michael B. Kimmey +4 more
It is concluded that misoprostol can protect the normal gastroduodenum from acute ulceration and reduce the chance of erosion after 1 wk of aspirin ingestion.
PubMedA double-blind placebo-controlled comparison of the efficacy and safety of 50, 100, and 200 micrograms of misoprostol QID in the prevention of ibuprofen-induced gastric and duodenal mucosal lesions and symptoms.
58 Citations1989Lanza Fl, Dan T. Fakouhi +5 more
It is concluded that misoprostol in both antisecretory and non-antisecretory doses protects the gastric mucosa from injury from high anti-inflammatory doses of ibuprofen (3200 mg/day).
British Medical BulletinPain control and the use of non-steroidal analgesic anti-inflammatory drugs
36 Citations1990G. Nuki
Strategies for minimising the risks of ADRs are discussed and emphasis is placed on using minimal analgesic, rather than anti-inflammatory, doses of short-acting NSAIDs and where possible avoiding their use in high risk patients.
Postgraduate Medical JournalClinical pharmacology and therapeutics
16 Citations1991Richard Horton, M. J. Kendall
Lara D. VeekenNSAID-ASSOCIATED GASTROPATHY—A ROLE FOR MISOPROSTOL?
8 Citations1990Neil Hopkinson, Michael Doherty
Misoprostol (Cytotec) is a prostaglandin E 1 analogue aimed specifically at healing and prophylaxis of nonsteroidal anti-inflammatory drug (NSAID) associated peptic ulceration.
Aktuelle RheumatologieBehandlung NSAR-induzierter gastrointestinaler Beschwerden durch Komedikation mit dem Prostaglandin-Analogon Misoprostol bei Patienten mit einer chronischen Polyarthritis
7 Citations1989W. Bolten