Methylphenidate decreases regional cerebral blood flow in normal human subjects
Life SciencesPublished 1 January 1994
Gene‐Jack Wang, Nora D. Volkow, Joanna S. Fowler, Richard A. Ferrieri, David J. Schlyer, David Alexoff
Citations34
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.
Abstract
To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5 mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25 +/- 11%) and at 30 minutes (20 +/- 10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.
Keywords
MedicineNeuroscience
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