Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder
Biological PsychiatryPublished 2 October 2007Open access
F. Xavier Castellanos, Daniel S. Margulies, Clare Kelly, Lucina Q. Uddin, Manely Ghaffari, Andrew J. Kirsch
Citations868
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is suggested that the long-range connections linking dorsal anterior cingulates to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
Abstract
Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
Keywords
MedicineNeuroscience
Proceedings of the National Academy of SciencesA default mode of brain function
12,398 Citations2001Marcus E. Raichle, Ann Mary MacLeod +4 more
A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors.
Magnetic Resonance in MedicineFunctional connectivity in the motor cortex of resting human brain using echo‐planar mri
10,089 Citations1995Bharat B. Biswal, F. Zerrin Yetkin +2 more
Proceedings of the National Academy of SciencesThe human brain is intrinsically organized into dynamic, anticorrelated functional networks
8,846 Citations2005Michael Fox, Abraham Z. Snyder +4 more
It is suggested that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain, featuring the presence of anticorrelated networks in the absence of overt task performance.
Psychological BulletinBehavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD.
7,285 Citations1997Russell A. Barkley
A theoretical model that links inhibition to 4 executive neuropsychological functions that appear to depend on it for their effective execution is constructed and finds it to be strongest for deficits in behavioral inhibition, working memory, regulation of motivation, and motor control in those with ADHD.
Trends in Cognitive SciencesCognitive and emotional influences in anterior cingulate cortex
6,248 Citations2000George Bush, George Bush +4 more
Various findings are reviewed in relation to the idea that ACC is a part of a circuit involved in a form of attention that serves to regulate both cognitive and emotional processing, and how the success of this regulation in controlling responses might be correlated with cingulate size.
BrainThe precuneus: a review of its functional anatomy and behavioural correlates
5,189 Citations2006Andrea E. Cavanna, Michael Trimble
A useful conceptual framework is provided for matching the functional imaging findings with the specific role(s) played by this structure in the higher-order cognitive functions in which it has been implicated, and activation patterns appear to converge with anatomical and connectivity data in providing preliminary evidence for a functional subdivision within the precuneus.
NeuroImageA Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
4,601 Citations2001Catriona D. Good, Ingrid S. Johnsrude +4 more
Proceedings of the National Academy of SciencesConsistent resting-state networks across healthy subjects
4,400 Citations2006Jessica S. Damoiseaux, Serge A.R.B. Rombouts +5 more
Findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.
Proceedings of the National Academy of SciencesDefault-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
3,723 Citations2004Michael D. Greicius, Gaurav Srivastava +2 more
A goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD.
Biological PsychiatryValidity of the Executive Function Theory of Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review
3,457 Citations2005Erik G. Willcutt, Alysa E. Doyle +3 more
Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD, and moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD.
American Journal of PsychiatryThe Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication
2,956 Citations2006Ronald C. Kessler
Efforts are needed to increase the detection and treatment of adult ADHD and research is needed to determine whether effective treatment would reduce the onset, persistence, and severity of disorders that co-occur with adult ADHD.
American Journal of PsychiatryThe Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication
2,802 Citations2006Ronald C. Kessler, Lenard A. Adler +12 more
Brain and DevelopmentAltered baseline brain activity in children with ADHD revealed by resting-state functional MRI
2,683 Citations2006Zang Yu-Feng, He Yong +7 more
A new marker of functional magnetic resonance imaging, amplitude of low-frequency fluctuation (ALFF) fluctuation, is used to investigate the baseline brain function of children with attention deficit hyperactivity disorder and suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.
The NeuroscientistSmall-World Brain Networks
2,678 Citations2006Danielle S. Bassett, Edward T. Bullmore
The authors consider the relevance of small-world models for understanding the emergence of complex behaviors and the resilience of brain systems to pathological attack by disease or aberrant development and conclude that small- world models provide a powerful and versatile approach to understanding the structure and function of human brain systems.
Human Brain MappingFunctional and effective connectivity in neuroimaging: A synthesis
2,511 Citations1994Karl Friston
This article presents one approach that has been used in functional imaging and shows how the integration within and between functionally specialized areas is mediated by functional or effective connectivity.
Biological PsychiatryResting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus
2,284 Citations2007Michael D. Greicius, Benjamin Flores +6 more
The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression and suggest that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects.
NeuroImageA default mode of brain function: A brief history of an evolving idea
2,203 Citations2007Marcus E. Raichle, Abraham Z. Snyder
This work determined that activity decreases in functional neuroimaging data did not arise from activations in the resting state, and thereby implied the existence of a default mode of brain function.
Journal of NeuroscienceMolecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
2,147 Citations2005Randy L. Buckner, Abraham Z. Snyder +9 more
One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
Nature NeuroscienceThe neural bases of momentary lapses in attention
1,606 Citations2006Daniel H. Weissman, Kenneth Roberts +2 more
It is determined that attentional lapses begin with reduced prestimulus activity in anterior cingulate and right prefrontal regions involved in controlling attention, and increased stimulus-evoked activity in the right inferior frontal gyrus and the right temporal-parietal junction predicted better performance on the next trial.
Human Brain MappingSpontaneous low‐frequency BOLD signal fluctuations: An fMRI investigation of the resting‐state default mode of brain function hypothesis
1,407 Citations2005Peter Fransson
The findings presented here suggest that the brain recurrently toggles between an introspectively oriented mode (default mode) and a state‐of‐mind that tentatively might be interpreted as an extrospectivelyoriented mode that involves a readiness and alertness to changes in the external and internal environment.
Journal of the American Academy of Child & Adolescent PsychiatryA Meta-Analysis of Working Memory Impairments in Children With Attention-Deficit/Hyperactivity Disorder
1,269 Citations2005Rhonda Martinussen, Jill A. Hayden +2 more
Evidence of WM impairments in children with ADHD supports recent theoretical models implicating WM processes in ADHD and is needed to more clearly delineate the nature, severity, and specificity of the impairments to ADHD.
Trends in Cognitive SciencesCharacterizing cognition in ADHD: beyond executive dysfunction
1,156 Citations2006F. Xavier Castellanos, Edmund Sonuga‐Barke +2 more
This work proposes an integrative model that incorporates new neuroanatomical findings and emphasizes the interactions between parallel processing pathways as potential loci for dysfunction in ADHD and suggests a plan for future research on cognition grounded in neurophysiological and developmental considerations.
Biological PsychiatryCausal Models of Attention-Deficit/Hyperactivity Disorder: From Common Simple Deficits to Multiple Developmental Pathways
946 Citations2004Edmund Sonuga‐Barke
Two theoretical models built around the idea of multiple neurodevelopmental pathways of attention-deficit/hyperactivity disorder are elaborated, reviewing their relationship to one another in the light of recent data suggesting that delay aversion and executive functions might each make distinctive contributions to the development of the disorder.
Neuroscience & Biobehavioral ReviewsSpontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis
891 Citations2007Edmund Sonuga‐Barke, F. Xavier Castellanos
An alternative hypothesis is reviewed: that spontaneous patterns of very low frequency (<0.1 Hz) coherence within a specific brain network thought to support a pattern of generalized task-non-specific cognition during rest, can persist or intrude into periods of active task-specific processing, producing periodic fluctuations in attention that compete with goal-directed activity.
Journal of NeuroscienceBrain Connectivity Related to Working Memory Performance
875 Citations2006Michelle Hampson, Naomi Driesen +3 more
Investigating the functional connectivity between the PCC and MFG/vACC during a working memory task and at rest by examining temporal correlations in magnetic resonance signal levels found the two regions were functionally connected in both conditions.
NeuroImageMapping the functional connectivity of anterior cingulate cortex
762 Citations2007Daniel S. Margulies, Clare Kelly +4 more
Journal of Child Psychology and PsychiatryThe neural correlates of attention deficit hyperactivity disorder: an ALE meta‐analysis
749 Citations2006Steven G. Dickstein, Katie Bannon +2 more
The present work provides an objective, unbiased statistically-based meta-analysis of published functional neuroimaging studies of ADHD, suggestive of the primacy of deficits in frontal-based neural circuitry underlying ADHD.
Archives of General PsychiatryLongitudinal Mapping of Cortical Thickness and Clinical Outcome in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
696 Citations2006Philip Shaw, Jason P. Lerch +7 more
Children with ADHD show relative cortical thinning in regions important for attentional control, and right parietal cortex thickness normalization in patients with a better outcome may represent compensatory cortical change.
Journal of Cognitive NeuroscienceDefault-Mode Activity during a Passive Sensory Task: Uncoupled from Deactivation but Impacting Activation
696 Citations2004Michael D. Greicius, Vinod Menon
Time-series analysis of default-mode activity provides a measure of the degree to which a task engages a subject and whether it is sufficient to interrupt the processes presumably cognitive, internally generated, and involving episodic memorymediated by the default- mode network.
Proceedings of the National Academy of SciencesFailing to deactivate: Resting functional abnormalities in autism
550 Citations2006Daniel P. Kennedy, Elizabeth Redcay +1 more
It is speculated that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism.
Biological PsychiatryVarieties of Attention-Deficit/Hyperactivity Disorder-Related Intra-Individual Variability
543 Citations2005F. Xavier Castellanos, Edmund Sonuga‐Barke +4 more
Secondary data analyses support the speculative hypothesis that the increased power of multisecond oscillations in ADHD RT data, and by inference, in attentional performance, represents a catecholaminergic deficit in the ability to appropriately modulate such oscillation in neuronal activity.
Neural NetworksConnectivity and complexity: the relationship between neuroanatomy and brain dynamics
541 Citations2000Olaf Sporns, Giulio Tononi +1 more
It is found that specific neuroanatomical motifs are uniquely associated with high levels of complexity and that they are embedded in the pattern of long-range cortico-cortical pathways linking segregated areas of the mammalian cerebral cortex.
Cerebral CortexCortical Thinning of the Attention and Executive Function Networks in Adults with Attention-Deficit/Hyperactivity Disorder
449 Citations2006Nikos Makris, Joseph Biederman +7 more
This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF, and this network is located in the right hemisphere involving the inferior parietal lobule, the dorsolateral prefrontal, and the anterior cingulate cortices.
NeuroreportWidespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging
404 Citations2006Meng Liang, Yuan Zhou +5 more
Experimental results indicated a decreased functional connectivity in schizophrenia during rest, and such abnormalities were widely distributed throughout the entire brain rather than restricted to a few specific brain regions.
Neuroscience LettersAltered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder
398 Citations2006Lixia Tian, Tianzi Jiang +9 more
Resting-state low-frequency fluctuations of blood oxygen level-dependent fMRI signals are used to investigate the resting-state functional connectivity pattern differences of dACC in adolescents with and without ADHD and suggest these abnormally more significant functional connectivities in the ADHD patients may indicate the abnormality of autonomic control functions in them.
Psychiatric Clinics of North AmericaDiagnosis and evaluation of adults with attention-deficit/hyperactivity disorder
295 Citations2004Lenard A. Adler, Julie Cohen
Although some areas of adult ADHD knowledge remain unclear, there is a strong sense of how to proceed with diagnosis using current DSM-IV criteria as a guide and the clinician-administered interview remains the cornerstone of diagnostic evaluation.
Neuroscience LettersGlobal and regional gray matter reductions in ADHD: A voxel-based morphometric study
290 Citations2005Susanna Carmona, Óscar Vilarroya +9 more
The results are consistent with previous studies that used different techniques, and may represent a possible neural basis for some of the motor and attentional deficits commonly found in ADHD.
Psychological MedicineDistributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network
211 Citations2001S Overmeyer, Edward T. Bullmore +5 more
This pattern of spatially distributed grey matter deficit in the right hemisphere is compatible with the hypothesis that ADHD is associated with disruption of a large scale neurocognitive network for attention.
NeuropsychologiaFunctional brain correlates of response time variability in children
143 Citations2007Daniel J. Simmonds, Sunaina Fotedar +4 more
The findings suggest that during response inhibition, children with more consistent performance are able to rely on premotor circuits involving the pre-SMA, important for response selection; those with less consistent performance instead recruit prefrontal circuits involved in more complex aspects of behavioral control.
