Role of GPR30 in endometrial pathology after tamoxifen for breast cancer
American Journal of Obstetrics and GynecologyPublished 21 October 2010
Tanja Ignatov, Holm Eggemann, Andrzej Semczuk, Bobbie Smith, Joachim Bischoff, Albert Roessner
Citations41
SJR quartileQ1
SJR score2.77
SNIP2.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
G-protein-coupled estrogen receptor plays an important role in tamoxifen-induced endometrial abnormalities, and was predictive of an earlier development of symptoms, such as bleeding or suspectendometrial thickness, induced by tamoxIFen therapy.
Abstract
G-protein-coupled estrogen receptor plays an important role in tamoxifen-induced endometrial abnormalities.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
The LancetEffects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
7,563 Citations2005
The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
JNCI Journal of the National Cancer InstituteTamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
5,508 Citations1998Bernard Fisher, Joseph P. Costantino +15 more
Tamoxifen decreases the incidence of invasive and noninvasive breast cancer and its use as a breast cancer preventive agent is appropriate in many women at increased risk for the disease.
ScienceA Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2,274 Citations2005Chetana M. Revankar, Daniel F. Cimino +3 more
It is found that of all G protein–coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives.
EndocrinologyIdentity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
1,379 Citations2004Peter Thomas, Yefei Pang +2 more
GPR30, an orphan receptor unrelated to nuclear estrogen receptors, has all the binding and signaling characteristics of a mER, and the identification of a second distinct class of GPCR-like steroid membrane receptors suggests a widespread role for GPCRs in nonclassical steroid hormone actions.
Journal of Biological ChemistryThe Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling
1,205 Citations2001Julie M. Hall, John F. Couse +1 more
This minireview will discuss the recent progress toward the understanding of the molecular mechanisms of estrogen signaling, focusing on the following four pathways: 1) classical ligand-dependent; 2) ligand -independent; 3) DNA binding-independent; and 4) cell-surface (nongenomic) signaling.
The LancetADJUVANT TAMOXIFEN IN EARLY BREAST CANCER: OCCURRENCE OF NEW PRIMARY CANCERS
930 Citations1989Tommy� Fornander, Björn Cedermark +10 more
The frequency of new primary cancers was studied in 1846 postmenopausal patients included in a randomised trial of tamoxifen as an adjunct to primary surgery for early breast cancer and the increase in endometrial cancers was most pronounced in those treated for over 2 years.
Human Reproduction UpdateSteroid hormone receptors: an update
607 Citations2000Miguel Beato
By all these different mechanisms SHRs modulate numerous and specific responses in a large variety of cells, whereby their particular effect depends on the physiological, cellular and genetic context.
Annual Review of PhysiologyEstrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
584 Citations2008Eric R. Prossnitz, Jeffrey B. Arterburn +4 more
An overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and the relationship of G PR30 with classical estrogen receptors is provided.
The LancetRisk of endometrial cancer after tamoxifen treatment of breast cancer
571 Citations1994Flora E. van Leeuwen, Alexandra W. van den Belt‐Dusebout +12 more
The hypothesis that tamoxifen use increases the risk of endometrial cancer is supported, as the oestrogenic effect on the endometrium was not related to the dose intensity.
Endocrine ReviewsNongenomic Actions of Steroid Hormones in Reproductive Tissues*
376 Citations1998Alberto Revelli, M Massobrio +1 more
Cross-Talk between the Nongenomic and Genomic Responses of Cells to Steroids VII shows that the GABAA-like receptor/Cl− channel and the PTK system are important sources of uncertainty in the mechanism behind the effects of estrogens.
The Journal of Steroid Biochemistry and Molecular BiologyEpidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
367 Citations2002Edward J. Filardo
GPCR-mediated transactivation of EGFRs by estrogen provides a previously unappreciated mechanism of cross-talk between estrogen and serum growth factors, and explains prior data reporting the EGF-like effects of estrogen.
Clinical Cancer ResearchDistribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression
360 Citations2006Edward J. Filardo, C. T. Graeber +6 more
The hypothesis that GPR30 and ER have an independent influence on estrogen responsiveness in breast carcinoma is supported by results that support the hypothesis.
Proceedings of the National Academy of SciencesEstrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium
339 Citations1999Teresa Improta-Brears, A. Richard Whorton +4 more
Data indicate that the estrogen receptor, in addition to functioning as a transcription factor, is also involved, through a nongenomic mechanism, in the regulation of both intracellular calcium homeostasis and MAPK-signaling pathways.
Molecular EndocrinologyThe G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17β-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells
337 Citations2005Adele Vivacqua, Daniela Bonofiglio +5 more
A new mode of action of E2 and OHT in endometrial cancer cells is demonstrated, contributing to a better understanding of the molecular mechanisms involved in their uterine agonistic activity.
Nature reviews. CancerMolecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
241 Citations2006Yongfeng Shang
Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation, and affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2.
JNCI Journal of the National Cancer InstituteTamoxifen Treatment for Breast Cancer and Risk of Endometrial Cancer: A Case-Control Study
222 Citations2005Anthony J. Swerdlow, Michael E. Jones +1 more
There is an increasing risk of endometrial cancer associated with longer tamoxifen treatment, extending well beyond 5 years, and should be considered clinically for both premenopausal and postmenopausal women during treatment and for at least 5 years after the last treatment.
American Journal of Obstetrics and GynecologyGPR30: a novel indicator of poor survival for endometrial carcinoma
212 Citations2007Harriet O. Smith, Kimberly K. Leslie +5 more
GPR30 represents an alternative estrogen-responsive receptor that is overexpressed in tumors where estrogen and progesterone receptors are downregulated, and in high-risk endometrial cancer patients with lower survival rates.
Journal of Clinical PathologyPathology of endometrium treated with tamoxifen.
198 Citations1994S M Ismail
Findings support a link between prolonged tamoxifen treatment and endometrial malignancy and identify a subgroup of patients, those who have taken more than 35 g of tamoxIFen, who may be at increased risk ofendometrial cancer.
Breast Cancer Research and TreatmentRole of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells
167 Citations2009Atanas Ignatov, Tanja Ignatov +3 more
Data suggests the important role of GPR30/EGFR receptor signaling in the development of tamoxifen resistance and the inhibition of this pathway is a valid option to improve anti-hormone response in breast cancer.
Cancer ResearchStimulating the GPR30 Estrogen Receptor with a Novel Tamoxifen Analogue Activates SF-1 and Promotes Endometrial Cell Proliferation
154 Citations2009Benjamin C. Lin, Miyuki Suzawa +5 more
It is proposed that this novel GPR30/SF-1 pathway increases local concentrations of estrogen, and together with classic ER signaling, mediate the proliferative effects of synthetic estrogens such as tamoxifen, in promoting endometriosis and endometrial cancers.
The Journal of Steroid Biochemistry and Molecular BiologyThe ins and outs of GPR30: A transmembrane estrogen receptor
148 Citations2008Eric R. Prossnitz, Tudor I. Oprea +2 more
This work has identified a novel GPR30 agonist that exhibits high specificity for G PR30 and describes recent work to further the understanding of the role of GPR 30 in estrogen biology.
Gynecologic OncologyComparison of Endometrial Changes among Symptomatic Tamoxifen-Treated and Nontreated Premenopausal and Postmenopausal Breast Cancer Patients
137 Citations1997Wen‐Fang Cheng, Ho‐Hsiung Lin +2 more
Journal of Clinical OncologyTamoxifen in premenopausal patients with metastatic breast cancer: a review.
124 Citations1991Margaret C. Sunderland, C. Kent Osborne
Tamoxifen has an attractive toxicity profile, and it offers a favorable therapeutic alternative for premenopausal women with ER-positive metastatic breast cancer who wish to avoid surgical or radiation castration.
British Journal of PharmacologyRANTES stimulates Ca<sup>2+</sup> mobilization and inositol trisphosphate (IP<sub>3</sub>) formation in cells transfected with G protein‐coupled receptor 75
109 Citations2006Atanas Ignatov, Jacques Robert +2 more
It is shown for the first time that RANTES activates the orphan G protein‐coupled receptor 75 (GPR75) in T‐lymphocyte activation and proliferation.
Biochemical and Biophysical Research CommunicationsSphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway
69 Citations2003Atanas Ignatov, Julia Lintzel +2 more
The mouse orthologue of human GPR6 is identified and cloned as a new member of the lysophospholipid-receptor family, with high specificity and nanomolar affinity, and required activation of sphingosine kinase and was accompanied by an increase in MAP-kinase phosphorylation.
The Journal of Steroid Biochemistry and Molecular BiologyInfluence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal breast cancer patients
68 Citations1995Per Eystein Lønning, Dag Clement Johannessen +4 more
Plasma levels of E1S together with unconjugated estrogens (E1 and E2), androgens (T, A, DHEA and DHEAS), SHBG, FSH and LH in 32 postmenopausal breast cancer patients before and during tamoxifen treatment were measured to evaluate the influence of tamoxIFen treatment on estrogen metabolism and total estrogen production.
Annals of OncologyBreast cancer prognostication and prediction in the postgenomic era
63 Citations2007Per Eystein Lønning, Stian Knappskog +3 more
Clinical settings for studying drug resistance in vivo together with a discussion of contemporary biology in this field are discussed, and it is suggested drug resistance may be explored on the basis of upfront biological hypotheses.
PubMedEffects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens.
45 Citations2007Kim LeBlanc, Émilie Sexton +5 more
The results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process.
Cancer ScienceAPC promoter hypermethylation is an early event in endometrial tumorigenesis
44 Citations2009Atanas Ignatov, Joachim Bischoff +8 more
The results suggest that hypermethylation of APC promoter region is an early event in endometrial tumorigenesis and no correlation between APC and E‐cadherin methylation patterns and the other clinicopathologic features, nor with patient outcome.
Breast Cancer ResearchWhat does an orphan G-protein-coupled receptor have to do with estrogen?
36 Citations2005James M. Rae, Michael D. Johnson
It has long been postulated that the rapid effects of estrogen are due to a membrane-bound ER, and two recent reports suggest that it is in fact a G-protein-coupled receptor named 'GPR30'.