Genome-wide association study of hematological and biochemical traits in a Japanese population
Nature GeneticsPublished 7 February 2010
Yoichiro Kamatani, Koichi Matsuda, Yukinori Okada, Michiaki Kubo, Naoya Hosono, Yataro Daigo
Citations535
SJR quartileQ1
SJR score16.59
SNIP6.64
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TL;DR
60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels were identified and compared with those reported in similar GWAS in European populations.
Abstract
We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P 10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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