Study of naloxone in normal awake man: Effects on heart rate and respiration
NeuropharmacologyPublished 1 May 1979
Willer Jc, F. Boureau, C. Dauthier, M. Bonora
Citations58
SJR quartileQ1
SJR score1.59
SNIP1.17
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TL;DR
There was no significant difference between the results obtained with naloxone and those with placebo and these data are discussed in relation to the regulation of the endogenous morphine-like systems, in normal and pathological subjects.
Abstract
A double-blind study, on the effects of naloxone (1.2 mg; 3 cm3; i.v.) and of placebo (9% NaCl serum, 3 cm3; i.v.) on the components of the ventilatory response and on heart rate, was undertaken in normal awake human subjects. Neither naloxone nor placebo produced significant changes in the parameters studied; moreover, there was no significant difference between the results obtained with naloxone and those with placebo. These data are discussed in relation to the regulation of the endogenous morphine-like systems, in normal and pathological subjects.
Keywords
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