Ocular autonomic function in progressive autonomic failure

Documenta OphthalmologicaPublished 1 December 1988

Charles V. Clark, D J Ewing

DOI10.1007/bf00157061

Source URL

Citations14

SJR quartileQ2

SJR score0.84

SNIP1.19

TL;DR

Ocular autonomic function was assessed in 4 patients with progressive autonomic failure and age-matched control subjects, and determination of autonomic denervation hypersensitivity of the iris suggested to provide a sensitive early indicator of generalised autonomic dysfunction.

Abstract

Ocular autonomic function was assessed in 4 patients with progressive autonomic failure (PAF) and age-matched control subjects, by measurement of the pupil cycle time, and determination of autonomic denervation hypersensitivity of the iris. Pupil cycle time was abnormal in all patients with PAF; sustained pupil cycling was absent in 5 of the 8 eyes tested of the PAF patients, compared with only 16 eyes from 70 control subjects. Pupil constriction in response to 2.5% methacholine, indicative of parasympathetic denervation hypersensitivity, was significantly increased in patients with PAF (p less than 0.001), whilst pupil dilation in response to 0.5% phenylephrine, indicative of sympathetic denervation hypersensitivity, was also significantly higher in the PAF patients (p less than 0.001). The results suggest that ocular autonomic function may provide a sensitive early indicator of generalised autonomic dysfunction.

Keywords

Medicine

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