Stereospecific Nickel‐Catalyzed Cross‐Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti‐Breast‐Cancer Agents
Angewandte Chemie International EditionPublished 29 January 2014
Ivelina M. Yonova, A. George Johnson, Charlotte A. Osborne, Curtis E. Moore, Naomi S. Morrissette, Elizabeth R. Jarvo
Citations154
SJR quartileQ1
SJR score5.55
SNIP2.47
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TL;DR
Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp-3)) bonds, which exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.
Abstract
Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.
Keywords
Chemistry
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