The debate over maternal-fetal HIV transmission prevention trials in Africa, Asia, and the Caribbean: racist exploitation or exploitation of racism?
American Journal of Public HealthPublished 1 April 1998Open access
R Bayer
Citations91
SJR quartileQ1
SJR score1.93
SNIP1.60
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The ethical dilemma should not be so much over whether or not the trial research design is appropriate but rather whether the inequitable distribution of wealth inherent to the current world economic order which necessitates finding a cheaper prophylaxis is morally sound.
Abstract
The debate over maternal-fetal HIV transmission prevention trials in Africa, Asia, and the Caribbean: racist exploitation or exploitation of racism? R BayerCopyRight https://doi.org/10.2105/AJPH.88.4.567 Published Online: October 07, 2011
Keywords
Medicine
New England Journal of MedicineReduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment
3,741 Citations1994Edward M. Connor, Rhoda Sperling +18 more
In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds.
New England Journal of MedicineUnethical Trials of Interventions to Reduce Perinatal Transmission of the Human Immunodeficiency Virus in Developing Countries
885 Citations1997Peter Lurie, Sidney M. Wolfe
The authors oppose the use of placebo-controlled trials as unethical in the search for alternative antiretroviral drug regimens to prevent the perinatal transmission of HIV.
New England Journal of MedicineThe Ethics of Clinical Research in the Third World
862 Citations1997Marcia Angell
An essential ethical condition for a randomized clinical trial comparing two treatments for a disease is that there be no good reason for thinking one is better than the other.
New England Journal of MedicineEthical Complexities of Conducting Research in Developing Countries
430 Citations1997Harold Varmus, D Satcher
The current debate hinges on the morality of using a placebo control when the AIDS Clinical Trials Group protocol 076 is being effectively used in other parts of the world and the most compelling response to criticisms of the placebo-control test designs is that it provides definitive answers to safety and effectiveness questions in the study setting.