Immunofluorescent localization of β-Corticotropin in the rat pituitary
Cellular and Molecular Life SciencesPublished 1 June 1968
R. Hess, Dean Barratt, J Gelzer
Citations27
SJR quartileQ1
SJR score2.30
SNIP1.48
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Unter Verwendung eines spezifischen Anti-β1–24-Corticotropin-Serums vom Kaninchen wurde β-Corticotropin immunhistologisch in der Rattenhypophyse nachgewiesen. Neben den Epithelien der Pars intermedia konnte kortikotropes Hormon in einem besonderen, mukoiden Zelltypus der Adenohypophyse lokalisiert werden.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
ScienceAntibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology
815 Citations1964Theodore L. Goodfriend, Lawrence Levine +1 more
Antibodies to bradykinin and angiotensin have been produced in rabbits by the use of conjugates containing albumin and the hapten, covalently bound using water-soluble carbodiimide reagents.
The Journal of Experimental MedicineLOCALIZATION OF ADRENOCORTICOTROPIC HORMONE BY HISTOCHEMICAL AND IMMUNOCHEMICAL METHODS
123 Citations1951John M. Marshall
The fluorescent antibody technique was adapted to the localization of native protein antigens in cells and tissues and gave a precipitin reaction with a highly active ACTH preparation of low molecular weight.
EndocrinologyCorticotrophs in the Anterior Pituitary Glands of Normal and Adrenalectomized Rats as Revealed by Electron Microscopy
121 Citations1966Kazumasa Kurosumi, Yasuo Kobayashi
A new type of granulated cell was found in pituitaries of both the normal and adrenalectomized animals, designated by us as a corticotroph, characterized by small secretory granules and a polyhedral or retort-like outline of the cell body.
Helvetica Chimica ActaSynthese eines Tetracosapeptides mit hoher corticotroper Wirksamkeit: β<sup>1–24</sup>‐Corticotropin
96 Citations1963R. Schwyzer, H. Kappeler
A new scheme for the protection of amino and carboxyl groups in the side chains of amino-acid residues was developed and led to a blocked tetracosapeptide II which contains only protective groups derived from t-butanol.
The Journal of Cell BiologyIDENTIFICATION OF THE ADRENOCORTICOTROPHIN-PRODUCING CELLS IN THE RAT HYPOPHYSIS BY AUTORADIOGRAPHY
69 Citations1963Eleanor R. Siperstein
PubMedThree types of chromophil cells of the adenohypophysis; demonstrated by a modification of the periodic acid-Schiff technique.
58 Citations2003W. David Wilson, C. Ezrin
PubMedThe functional cytology of the human adenohypophysis.
52 Citations1963Pearse Ag, Van Noorden S
Although each of the hormones may be derived from a single cell type, present evidence has suggested that three or perhaps four cell types share the production of the seven known hormones and of any which remain to be discovered.
Journal of Clinical InvestigationTHE CYTOLOGICAL LOCALIZATION OF ACTH IN THE HUMAN PITUITARY*
39 Citations1962A. Leznoff, J. Fishman +4 more
Journal of Scientific InstrumentsRapid freeze-drying of biological tissues with a thermoelectric unit
18 Citations1963A. G. E. Pearse
ImmunochemistryImmunochemical study of β-corticotropin-(1–24)-tetracosa-peptide
16 Citations1968J Gelzer
Quantitative inhibition studies with various ACTH peptides clearly demonstrated that the specificity of the rabbit anti- β 1–24 -corticotropin was complementary to the C-terminal part of the tetracosapeptide hormone, indicating that there may exist similar immunologically active portions on natural ACTH in addition to those described within the β 25–39 -sequence of ACTH.