The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
Current BiologyPublished 1 May 1996Open access
Brent W. Zanke, Kimberly Boudreau, Elizabeth A. Rubie, Elaine Winnett, Lee Anne Tibbles, Leonard I. Zon
Citations451
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
Experimentalally induced stable blockade of SAPK activation in cells with normal thermosensitivity is sufficient to confer resistance to cell death induced by diverse stimuli including heat and the chemotherapeutic agent cis-platinum.
Abstract
Experimentally induced stable blockade of SAPK activation in cells with normal thermosensitivity is sufficient to confer resistance to cell death induced by diverse stimuli including heat and the chemotherapeutic agent cis-platinum. These results suggest that activation of the SAPK pathway by diverse cell stressors plays a critical part in mediating the toxicity of these treatments and inducing cell death. SAPK activation in this context could broadly influence cellular response to stress, modulate apoptosis during development or determine the clinical response of tumor cells to cytotoxic therapies.
Keywords
Biochemistry, Genetics and Molecular Biology
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