Nonparametric analysis of dose-response relations in epidemiology
Mathematical ModellingPublished 1 January 1986
K. Ulm
Citations3
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TL;DR
A nonparametric method for the estimation of a dose-response relation is described and an application to data of an epidemiological study is presented.
Abstract
A nonparametric method for the estimation of a dose-response relation is described. Up to two quantitative covariates can be handled. Subject only to the constraints of monotonicity an estimation procedure together with an approach for testing the association is described. An application to data of an epidemiological study is presented.
Keywords
Decision Sciences
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The maximum likelihood estimate (MLE) of the dose-response relation for a single covariate is shown to be a step function with discontinuities only at the covariate values of the failures.
