Nuclear targeting sequences — a consensus?
Trends in Biochemical SciencesPublished 1 January 1991
Colin Dingwall, Ronald A. Laskey
Citations1,883
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
It is suggested in this review that, despite this diversity of nuclear targeting sequences, a consensus bipartite motif can be identified.
Abstract
Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been regarded as the model; however, many nuclear targeting sequences appear to be more complex. We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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