Maternal age and fetal loss: population based register linkage study
BMJPublished 24 June 2000Open access
Anne‐Marie Nybo Andersen
Citations1,657
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TL;DR
Fetal loss is high in women in their late 30s or older, irrespective of reproductive history, and should be taken into consideration in pregnancy planning and counselling.
Abstract
Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.
Keywords
Medicine
Human GeneticsMaternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
483 Citations1985Terry Hassold, Darryl Chiu
Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 years and older may be aneuploid.
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422 Citations1989L. Regan, Peter Braude +1 more
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213 Citations1998Matthias Egger, Nicola Low +3 more
Declining rates of genital chlamydial infections have probably led to a fall in the rate of ectopic pregnancies among young women, and among older women the associations were less pronounced.
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The effects of advanced maternal age, nulliparity, and smoking on risk of stillbirth as gestation advances are examined and possible clinical mediators of these effects are explored.
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The levels of risk of miscarriage found in this analysis are similar to those of previous studies, and the analytic methods suggest how age, obstetric history, and other factors can be simultaneously examined for associations with such risk.
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123 Citations1987Michael J. Bennett, D. Keith Edmonds +1 more
Early embryonic mortality Morphological analysis of spontaneous abortuses, psychological aspects of spontaneous abortion, and principles of management of spontaneous and recurrent abortion are presented.
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The results suggest that uterine aging also is a factor influencing the poor reproductive performance of women with advancing age, and suggests that the mechanism(s) responsible for placenta formation and functioning in the uterus is affected by age.
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A relatively small group of women has drastically changed the overall national rates of multiple pregnancies and the introduction of new treatments to enhance fertility has probably caused these changes and has also affected the otherwise decreasing trend in infant mortality.
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Two risk factors for fetal loss are confirmed: maternal age and number of prior spontaneous abortions and ethnic origin and psychological problems at the time of conception.
Early Human DevelopmentSpontaneous abortion: the role of heterogeneous risk and selective fertility
62 Citations1982Allen J. Wilcox, Beth C. Gladen
Three factors powerfully affect the occurrence of spontaneous abortion: a heterogeneous risk of abortion (constant for each woman but differing among women); selective fertility (a tendency to control fertility on the basis of previous pregnancy outcomes); and increased risk with maternal age.
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Evidence from more than 14,000 reproductive histories in the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke indicates that the risk of spontaneous abortion increases considerably with gravidity.
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3 Citations1996Per Søgaard, Møller Br +5 more
It is concluded that genital chlamydial infection among young asymptomatic people is common and screening would be desirable and urethral swabbing as the routine method until simpler and/or more reliable assays for urine specimens are developed.
PubMed[Presence of genital Chlamydia trachomatis in abortion seekers--correlates with young age and nulliparity but not with previous genital infection].
1 Citations1992Jette Led Sørensen, Thranov Ir +1 more
It is concluded that women under the age of 25 years and nulliparae who apply for termination of pregnancy should be examined for Chlamydia and should be treated in connection with the intervention.
