The turnover of myelin phosphatidylcholine and sphingomyelin in the adult rat brain
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TL;DR
The precursor-product relationship suggests myelin leCithin could originate from microsomal lecithin, and the apparent half-life of rapidly turning over pools of myelin and microsomes of adult rat brain is 4–6 days after an intracerebral injection of [methyl- 14 C]-choline.
Abstract
The apparent half-life of rapidly turning over pools of myelin and microsomal lecithin of adult rat brain is 4–6 days after an intracerebral injection of [methyl-14C]-choline. The slowly turning over myelin lecithin pool has a half-life of approximately 36 days. The apparent half-life for both microsomal and myelin sphingomyelin is estimated at around 33–35 days. After correction for deposition of newly synthesized lecithin and sphingomyelin during the term of the experiment, the apparent half-life of slowly turning over lecithin pool and sphingomyelin is estimated to be around 42 days and 41–44 days, respectively. The specific radioactivity of the precursors of lecithin,viz. phosphorylcholine and CDP-choline, 12 h after the injection was similar and declined similarly to microsomal lecithin. Isolated myelin does not appear to contain the enzyme CDP-choline-1,2-diglyceride choline phosphotransferase for the synthesis of lecithin. The precursor-product relationship suggests myelin lecithin could originate from microsomal lecithin.