Anatomic location and laterality of MRI signal hyperintensities in late-life depression
Journal of Psychosomatic ResearchPublished 1 August 2002
Larry A. Tupler, K. Ranga Krishnan, William M. McDonald, Carrie Dombeck, Sean D'Souza, David C. Steffens
Citations130
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TL;DR
Left-sided white-matter lesions were significantly associated with older age of depression onset, whereas right-anterior white matter and left-subcortical lesions (particularly in the putamen) were associated with melancholia in the depressed group.
Abstract
These findings extend previous reports of an association between cerebrovascular disease and depression, as well as recent studies showing lateralized lesion involvement in geriatric depression. Such vascular pathology may disrupt neural pathways involved in affective processing and the maintenance of a normal mood and psychomotor state.
Keywords
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DepressionMagnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder
31 Citations1993Kousik Krishnan, Orest B. Boyko +5 more
Some important methodological issues for measurement of brain structures and lesions visualized on magnetic resonance (MR) imaging include the method of sectioning, number of slices, shape of the structure, orientation of the slices, and fuzziness of the edges.
International PsychogeriatricsIs the Clinical Expression of Late-Life Depression Influenced by Brain Changes? MRI Subcortical Neuroanatomical Correlates of Depressive Symptoms
30 Citations2000Steve Simpson, R Baldwin +3 more
In late-life depression the clinical expression of the depression is influenced by the pattern of MRI T2-weighted subcorticallesions, which gives some validity to the concept of an MRI-defined “vascular” subtype of late- life depression and strengthens the argument for including neuroimaging in the classification of late, life depression.
Psychiatry Research NeuroimagingMagnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients
30 Citations1998David C. Steffens, Larry A. Tupler +2 more
Among depressed patients, older age of depression onset and greater severity of depression were associated with increased putamen nuclei iron deposition, which supports previous neuroimaging studies linking both changes in the basal ganglia and greater left-sided brain pathology to late-life depression.
The LancetGrey-matter lesions and dementia
27 Citations2000David C. Steffens, James R. MacFall +3 more
European Archives of Psychiatry and Clinical NeuroscienceMagnetic resonance in patients with affective illness
21 Citations1992William M. McDonald, K.Ranga Rama Krishnan
Magnetic resonance imaging has demonstrated brain changes in affective disorders that correlate with neuroendocrine findings and are similar to changes noted in normal aging.
International PsychogeriatricsAge of Onset and Medical Illness in Older Depressed Inpatients
18 Citations1995Jeffrey M. Lyness, Yeates Conwell +3 more
The usefulness of age of onset as a primary research variable for elucidating heterogeneity of late-life depression is reconsiders.
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