Predictors of freezing in Parkinson's disease: A survey of 6,620 patients
Movement DisordersPublished 20 March 2007
Michael Macht, Yvonne Kaußner, Jens Carsten Möller, Karin Stiasny‐Kolster, Karla Eggert, Hans‐Peter Krüger
Citations317
SJR quartileQ1
SJR score2.99
SNIP1.98
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TL;DR
The results underline the necessity to develop appropriate countermeasures against freezing, which is widely known to cause significant impairment of patients' quality of life and—as the data showed—may cause traffic accidents in licensed patients.
Abstract
Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty-seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and - as our data also showed - may cause traffic accidents in licensed patients.
Keywords
MedicineHealth Professions
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