Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
Journal of the American College of CardiologyPublished 1 November 1998Open access
Agha W. Haider, Martin G. Larson, Emelia J. Benjamin, Daniel Levy
Citations794
SJR quartileQ1
SJR score9.02
SNIP6.30
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TL;DR
Increased LV mass and hypertrophy are associated with increased risk for sudden death after accounting for known risk factors.
Abstract
Increased LV mass and hypertrophy are associated with increased risk for sudden death after accounting for known risk factors.
Keywords
Social SciencesMedicine
Analysis of Survival Data
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The estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors, and it is concluded that an increase in left Ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease.
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In men with mild uncomplicated hypertension, left ventricular hypertrophy detected by echocardiography identifies patients at high risk for cardiovascular morbid events and is a significant risk factor for future morbid events independent of age, blood pressure, or resting ventricular function.
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The American Journal of CardiologyEchocardiographic criteria for left ventricular hypertrophy: The Framingham heart study
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Until outcome guided criteria for LV hypertrophy are developed, application of sex-specific criteria based on a healthy population distribution of LV mass offer the best approach to echocardiographic diagnosis of LVhypertrophy.
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Echocardiographic assessment of left ventricular mass offers prognostic information beyond that provided by traditional risk factors, which can improve the ability to identify individuals at high risk for coronary heart disease.
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533 Citations1990Daniel Levy, Sherif B. Labib +4 more
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Electrocardiographic monitoring of patients with left ventricular hypertrophy allows identification of those who have the highest risk and, therefore, require the most aggressive therapeutic intervention.
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A spectrum of forms--eccentric-dilated, eccentric-nondilated, concentric, and disproportionate septal thickness--which varied in prevalence in the various age-sex groups was associated with higher systolic blood pressures at the time of echocardiographic examination and over the previous 30 years when compared with blood pressures of Framingham subjects without echo LVH.
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386 Citations1987Daniel Levy, Keaven M. Anderson +4 more
Echocardiographic LVhypertrophy is more prevalent and more sensitive for ventricular arrhythmias than ECG LV hypertrophy, and is associated with increased risk for each of 6 ventriculararrhythmia grades in men and women.
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The key to the prevention of sudden death in the general population is to prevent coronary attacks by avoidance or correction of the aforementioned risk factors.
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364 Citations1992Mary J. Roman, Pier Sergio Saba +6 more
The present study documents the presence of geometric and functional changes within the common carotid artery in uncomplicated hypertension that parallel findings within the left ventricle.
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330 Citations1990Jan L. Houghton, Martin J. Frank +3 more
It is demonstrated that thallium perfusion defects are associated with depressed coronary vasodilator reserve in hypertensive patients without obstructive coronary artery disease and left ventricular hypertrophy by indexed mass criteria is predictive of which hypertensive Patients are likely to have thalliam defects.
JAMAThe Relative Effects of Left Ventricular Hypertrophy, Coronary Artery Disease, and Ventricular Dysfunction on Survival Among Black Adults
330 Citations1995Youlian Liao
Left ventricular hypertrophy was associated with a greater RR and attributable risk than the traditional measures of coronary disease severity and may account for much of the black-white differential among black patients with heart disease.
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277 Citations1983Nathaniel Reichek, J Helak +3 more
Results compare favorably with reported results from biplane angiography and M-mode echocardiography in more symmetric hearts and suggest regression-corrected 2-D echo be the method of choice for determining LV mass in man.
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222 Citations1987Melvin L. Marcus, David G. Harrison +7 more
The recent observation that experimentally produced left ventricularhypertrophy secondary to renal hypertension augments infarct size and the incidence of sudden lethal arrhythmias has additional implications relevant to the interaction between cardiac hypertrophy and myocardial perfusion.
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221 Citations1983Julius Nathan Woythaler, S. Singer +5 more
M-mode echocardiography was technically adequate to evaluate the presence or absence of left ventricular hypertrophy more often than either electrocardiography or two-dimensional echOCardiography.
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Electrocardiographic LV hypertrophy heralds the onset of serious cardiovascular disease and premature mortality despite lack of associated symptoms and the serious prognosis of this abnormality warrants vigorous preventive management.
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191 Citations1990Richard Cooper, Brian Simmons +4 more
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Electrocardiographic abnormalities such as left ventricular hypertrophy, intraventricular block, and nonspecific repolarization abnormality were better short-term predictors of the long-term occurrence of SCD, and women had a lower incidence than men at all ages, and even after adjusting for known risk factors, their SCD rate was only 32% of that in men.
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Left ventricular hypertrophy is associated with an increase in the frequency and complexity of ventricular arrhythmias in the absence of coronary artery disease, and the relation is graded and continuous.
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172 Citations1993Jay M. Sullivan, Roger Vander Zwaag +3 more
It is concluded that ECG left ventricular hypertrophy has an adverse effect on survival, even in patients who are free of coronary artery disease.
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172 Citations1993Mahesh Bikkina, Martin G. Larson +1 more
In subjects with left ventricular hypertrophy, the presence of asymptomatic ventricular arrhythmias was associated with higher mortality, which was statistically significant after adjusting for age and gender and marginally significant after taking into account other covariates.
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In an epidemiologic study of the total population of Tecumseh, Michigan, 98 deaths from coronary heart disease were observed between 1959 and 1965, forty-five of the fatalities occurred within 1 hour of the onset of symptoms and were classified as sudden.
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ECG-LVH and ECG-MI are similar subclinical events with respect to predisposing characteristics and prognosis for subsequent overt cardiovascular disease including clinical manifestations of coronary heart disease, according to the Framingham study.
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129 Citations1992Alexei P. Yurenev, Helena G. Dyakonova +13 more
It is confirmed that beta-blockers can reduce mortality associated with the complications presented in hypertensive patients and Regression of LVH to less than 200 g (according to Teichholz' formula) improved prognosis.
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The increased incidence of sudden cardiac death after coronary artery occlusion in hypertensive LVH dogs cannot be explained by increased size of the occluded vascular bed and is probably related to the decreased coronary reserve or intrinsic electrophysiologic abnormalities that characterize pressure-induced hypertrophied cardiac muscle.
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The authors graphically studied the topographic pattern and severity of coronary arteriosclerosis in arteriosclerotic heart disease (ASHD) sudden deaths using an improved technique involving in toto removal and decalcification of the main coronary tree.
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103 Citations1988Wilbert S. Aronow, Stanley Epstein +2 more
27-month follow-up data are reported correlating LV hypertrophy, VT and complex ventricular arrhythmias with development of primary ventricular fibrillation (VF) or sudden cardiac death in these 554 unselected patients older than 62 years in a long-term health care facility.
CirculationEssential Hypertension
93 Citations1966Donald J. Breslin, Ray W. Gifford +1 more
This follow-up study was undertaken to clarify the natural history of essential hypertension and to investigate the prognostic value of ophthalmoscopic findings and other criteria.
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Measurement of QT dispersion might be a simple, non-invasive screening procedure to identify those hypertensives at greatest risk of sudden death.
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The rate of infarction is accelerated in animals with HT-LVH, and nitroprusside infused 1 hour after coronary artery occlusion and continued throughout the reperfusion period exerts beneficial effect on infarct size when compared with control animals.
The American Journal of CardiologyEchocardiographically determined left ventricular structural and functional correlates of complex or frequent ventricular arrhythmias on one-hour ambulatory electrocardiographic monitoring
36 Citations1987Daniel Levy, Keaven M. Anderson +4 more
Systolic LV internal diameter, which reflects both functional and structural information, is the only measurement independently predictive of arrhythmia risk in persons free of apparent heart disease.
Left Ventricular Hypertrophy
31 Citations1985Nathaniel Reichek, Martin G. St. John Sutton
Left ventricular hypertrophy is a fundamental component of cardiac adaptation to disorders which alter left ventricular pressure, volume or contractility on a chronic basis and permits the long asymptomatic phases observed in subjects with aortic stenosis, hypertensive heart disease, aorta regurgitation and mitral regurgitations.
American Journal of Physiology-Heart and Circulatory PhysiologyRelative importance of hypertension after coronary occlusion in chronic hypertensive dogs with LVH
27 Citations1987T Inou, Wade C. Lamberth +4 more
It is likely that hypertension, as opposed to LVH, is the critical factor responsible for the increase in infarct size and the high incidence of sudden death observed in dogs with hypertension and LVH following sudden coronary occlusion.