Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder
Current Opinion in NeurobiologyPublished 1 April 1998
James M. Swanson, F. Xavier Castellanos, Michael Murias, Gerald J. LaHoste, James L. Kennedy
Citations274
SJR quartileQ1
SJR score2.54
SNIP1.27
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TL;DR
Currently, diagnoses of attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD) are made on the basis of phenomenology, but information is accumulating from the neurosciences about the biological bases of these disorders.
Abstract
Currently, diagnoses of attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD) are made on the basis of phenomenology, but information is accumulating from the neurosciences about the biological bases of these disorders. Recent studies addressing the neuropsychology, neuroanatomy, neurochemistry, and molecular biology of ADHD/HKD document abnormalities in well-defined neuroanatomical networks and neurochemical pathways. Magnetic resonance imaging (MRI) studies have shown that some regions of the frontal lobes (anterior superior and inferior) and basal ganglia (caudate nucleus and globus pallidus) are about 10% smaller in ADHD groups than in control groups of children, and molecular genetic studies have shown that diagnosis of ADHD is associated with polymorphisms in some dopamine genes (the dopamine D4 receptor gene and the dopamine transporter gene).
Keywords
MedicineNeuroscience
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