Proliferation, cell cycle and apoptosis in cancer
NaturePublished 1 May 2001
Gérard I. Evan, Karen H. Vousden
Citations3,400
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Deregulated cell proliferation provides a minimal 'platform' necessary to support further neoplastic progression and should be targeted withroit targeting to have potent and specific therapeutic consequences.
Abstract
Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.
Keywords
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