Squamous Vulvar Intraepithelial Neoplasia
Clinical Obstetrics & GynecologyPublished 14 November 2005
Mario Preti, Manon van Seters, Mario Sideri, Marc van Beurden
Citations111
SJR quartileQ2
SJR score0.52
SNIP0.59
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TL;DR
The interdisciplinary work has allowed a deeper understanding of the biology, pathology, and clinical features of vulvar cancer precursors so that, even managed by a variety of healthcare providers from different specialties, today patients affected by VIN are offered comparable therapies.
Abstract
Preti, Mario MD; Seters, Manon Van MD; Sideri, Mario MD; Beurden, Marc Van MD Author Information
Keywords
Medicine
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PubMedEpidermal thickness and skin appendage involvement in vulvar intraepithelial neoplasia.
21 Citations1991J.L. Benedet, P S Wilson +1 more
The measurements suggest that laser vaporization to a depth of 1.0 mm, including the zone of thermal necrosis, should be sufficient to destroy most epidermal lesions without skin appendage involvement, and would be necessary to theoretically achieve greater than 90% elimination of the disease.
PubMedAnal involvement by carcinoma in situ of the perineum in women.
21 Citations1984Schlaerth Jb, Morrow Cp +2 more
The only noteworthy, long-term adverse effect of resecting the anal mucosa and replacing it with a split thickness skin graft was occasional incontinence of flatus in three of the 19 patients.
PubMedPregnancy-associated invasive squamous cell carcinoma of the vulva in a 28-year-old, HIV-negative woman. A case report.
20 Citations2000Debra S. Heller, Bernadette Cracchiolo +2 more
This case demonstrates the need to biopsy all suspicious vulvar lesions, even in young and pregnant women, and is reported on a 28-year-old woman who was diagnosed with invasive squamous cell carcinoma of the vulva during pregnancy.
ApmisHuman papillomavirus (HPV) in vulvar dysplasia and carcinoma <i>in situ</i>
17 Citations1995Jette Junge, Hemming Poulsen +3 more
The results indicate a correlation between HPV type 16 and 33 and dysplasia/carcinoma in situ in the vulva and pure forms of warty and basaloid types probably do not exist.
British Journal of Cancerp53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia
17 Citations2000Adam N. Rosenthal, Andy Ryan +2 more
It is concluded that the arginine polymorphism may confer protection against the development of HPV-associated vulval neoplasia.
International Journal of Gynecological CancerLaminin-5 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract
17 Citations2002B. Nordstrm, N. Einhorn +4 more
Positive laminin-5 &ggr; 2 chain expression seems to indicate the invasiveness potential of precancerous lesions and is also expressed in all investigated invasive carcinomas of the anogenital tract.
PubMedDifferentiating vulvar intraepithelial neoplasia from nonneoplastic epithelial disorders. The toluidine blue test.
17 Citations1998Elmar A. Joura, Harald Zeisler +3 more
Human PathologyMajor histocompatibility complex and human papillomavirus type 16 E7 expression in high-grade vulvar lesions
16 Citations1993Ingrid Jochmus, Matthias Dürst +5 more
A correlation between MHC and E7 expression appears unlikely in warty VIN lesions, although there was heterogeneous keratinocyte expression of MHC class II proteins, perhaps due to inflammation.
PubMedIntraepithelial carcinoma of the vulva with extension to the anal canal.
16 Citations1981Alan L. Kaplan, Raymond H. Kaufman +2 more
Ten patients with intraepithelial carcinoma of the vulva that extended to the anus were studied and treatment consisted predominantly of a skinning vulvectomy with split-thickness skin graft and excision of the anal disease.
Gynecologic OncologyHPV-16 viral transcripts in vulvar neoplasia: Preliminary studies
15 Citations1991J.S. Park, Janet S. Rader +5 more
In situ hybridization for the detection of subgenomic transcripts in four vulvar specimens revealed that the transcripts of the E6-E7 region were more abundant than those of the L1-L2 region in vulvar neoplastic tissues, suggesting that expression of HPV-16 is regulated by the degree of cellular differentiation.
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